Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/1022
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kabay, Gözde | - |
dc.contributor.author | Meydan, Ahmet Ersin | - |
dc.contributor.author | Kaleli Can, Gizem | - |
dc.contributor.author | Demirci, Ceylan | - |
dc.contributor.author | Mutlu, Mehmet | - |
dc.date.accessioned | 2019-05-23T05:48:44Z | |
dc.date.available | 2019-05-23T05:48:44Z | |
dc.date.issued | 2017-12 | |
dc.identifier.citation | Kabay, G., Meydan, A. E., Can, G. K., Demirci, C., & Mutlu, M. (2017). Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers. Materials Science and Engineering: C, 81, 271-279. | en_US |
dc.identifier.issn | 0928-4931 | |
dc.identifier.other | number of pages 9 | |
dc.identifier.uri | https://doi.org/10.1016/j.msec.2017.08.003 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/1022 | - |
dc.description.abstract | In this study, a controlled drug release platform, amyloid-like bovine serum albumin (AL-BSA) with ampicillin sodium salt (amp), was developed. To develop this platform, 5%, 10%, and 20% (w/w) ratios of amp:BSA were used with electrospinning to prepare nanofibers with average diameters of 132 +/- 69, 159 +/- 60, and 179 +/- 42 nm, respectively. Fourier transform infrared spectroscopy demonstrated that AL-BSA could entrap large amounts of drug inside the nanofibers, which was attributed to the antimicrobial activity of the released drug against Escherichia coli and Staphylococcus aureus. The amount of drug released was measured by UV-VIS spectrophotometry. The nanofibrous matrix of the electrospun membrane showed controlled release behavior in all samples. The transport mechanism was Fickian for the low ratio of amp:BSA (5% w:w). When the drug ratio was increased to > 10% (w:w), thicker fiber structures formed, suggesting that the drug traveled a longer distance to reach the fiber surface; thus, the mechanism of transport shifted from Fickian to non-Fickian. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science Bv | en_US |
dc.relation.ispartof | Materials Science & Engineering C-Materials For Biological Applications | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | drug release | en_US |
dc.subject | amyloid-like bovine serum albumin | en_US |
dc.subject | controlled release | en_US |
dc.subject | blend electrospinning | en_US |
dc.subject | ampicillin | en_US |
dc.title | Controlled Release of a Hydrophilic Drug From Electrospun Amyloid-Like Protein Blend Nanofibers | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Biomedical Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 81 | |
dc.identifier.startpage | 271 | |
dc.identifier.endpage | 279 | |
dc.authorid | 0000-0001-7146-1937 | - |
dc.authorid | 0000-0002-8594-3459 | - |
dc.identifier.wos | WOS:000410253800033 | en_US |
dc.identifier.scopus | 2-s2.0-85027517184 | en_US |
dc.institutionauthor | Mutlu, Mehmet | - |
dc.institutionauthor | Kabay, Gözde | - |
dc.identifier.pmid | 28887973 | en_US |
dc.identifier.doi | 10.1016/j.msec.2017.08.003 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.2. Department of Biomedical Engineering | - |
Appears in Collections: | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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