Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1030
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dc.contributor.authorSultanova, Zahida-
dc.contributor.authorKaleli, Gizem-
dc.contributor.authorKabay, Gözde-
dc.contributor.authorMutlu, Mehmet-
dc.date.accessioned2019-05-23T05:48:45Z
dc.date.available2019-05-23T05:48:45Z
dc.date.issued2016-05
dc.identifier.citationSultanova, Z., Kaleli, G., Kabay, G., & Mutlu, M. (2016). Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers. International journal of pharmaceutics, 505(1-2), 133-138.en_US
dc.identifier.issn0378-5173
dc.identifier.othernumber of pages 6
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2016.03.032-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1030-
dc.description.abstractA recent approach for controlled release of drugs is the production of core-shell fibers via modified coaxial electrospinning where a shell solution which is not fully electrospinnable can be used. In this study, this technique was used for achieving the controlled release of a model hydrophilic drug (ampicillin) which is known to have a low compatibility with the polymer (polycaprolactone). A partially electrospinnable shell fluid (4% (w/v) polycaprolactone (PCL) solution) and a fully electrospinnable core fluid (10% (w/v) PCL, 2% (w/v) ampicillin solution) were used in order to create ampicillin-loaded PCL nanofibers covered by a PCL shield. Scanning electron microscopy and optical microscopy images proved that the membranes have core-shell structured nanofibers. Fourier transform infrared spectroscopy demonstrated that some compatibility might be present between ampicillin and PCL. Finally, drug release studies showed that the drug release kinetics of core-shell products is closer to zero-order kinetics while the drug release kinetics of single electrospinning of the core resulted with serious burst release. Together, these imply that the application area of modified coaxial electrospinning in controlled release could be expanded to polymers and drugs with low compatibility. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal Of Pharmaceuticsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmodified coaxial electrospinningen_US
dc.subjectpolycaprolactoneen_US
dc.subjectzero order drug releaseen_US
dc.subjectcontrolled drug releaseen_US
dc.subjectampicillinen_US
dc.subjectcore-shell fibersen_US
dc.titleControlled Release of a Hydrophilic Drug From Coaxially Electrospun Polycaprolactone Nanofibersen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume505
dc.identifier.issue1.Şub
dc.identifier.startpage133
dc.identifier.endpage138
dc.authorid0000-0002-8594-3459-
dc.authorid0000-0001-7146-1937-
dc.identifier.wosWOS:000376695900016en_US
dc.identifier.scopus2-s2.0-84962815427en_US
dc.institutionauthorMutlu, Mehmet-
dc.institutionauthorKabay, Gözde-
dc.identifier.pmid27012983en_US
dc.identifier.doi10.1016/j.ijpharm.2016.03.032-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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