Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10321
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dc.contributor.authorÖzgüzar, Hatice Ferda-
dc.contributor.authorEvren, Ebru-
dc.contributor.authorMeydan, Ahmet Ersin-
dc.contributor.authorKabay, Gözde-
dc.contributor.authorGocmen, Julide Sedef-
dc.contributor.authorBüyükserin, Fatih-
dc.contributor.authorEroğul, Osman-
dc.date.accessioned2023-04-16T10:00:16Z-
dc.date.available2023-04-16T10:00:16Z-
dc.date.issued2023-
dc.identifier.issn2196-7350-
dc.identifier.urihttps://doi.org/10.1002/admi.202202009-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10321-
dc.description.abstractThe inferior hemocompatibility or antibacterial properties of blood-contacting materials and devices are restraining factors that hinder their successful clinical utilization. To highlight these, a plasma-enhanced modification strategy is favored for surface tailoring of an extensively used biomaterial, polypropylene (PP). The surface activation of the PPs is achieved by oxygen plasma etching and subsequent surface functionalization through amine-rich precursor mediated coating by plasma glow discharge. After optimum plasma processing parameters are decided, heparin (anticoagulant and antithrombic drug) is either attached or covalently conjugated on the PPs' surfaces. The aminated films produced at 75 W plasma power with 15 min exposure time are highly hydrophilic (34.72 +/- 5.92 degrees) and surface active (65.91 mJ m(-2)), facilitating high capacity heparin immobilization (approximate to 440 mu g cm(-2)) by covalent linkage. The kinetic-blood coagulation rate and protein adhesion amount on the plasma-mediated heparinized PPs are decreased about tenfold and 15-fold, and platelet adhesion is markedly lowered. In addition, heparinized-PP surfaces comprise superior antibacterial activity against gram-positive/-negative bacteria conveyed particularly by contact-killing (99%). The heparin-coating did not cause cytotoxicity on fibroblast cells, instead enhanced their proliferation, as shown by the (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay. Overall, this simple methodology is highly proficient in becoming a universal strategy for developing dual-functionalized blood-contacting materials.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAdvanced Materials Interfacesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiofilm formationen_US
dc.subjectclot formationen_US
dc.subjecthemocompatibilityen_US
dc.subjectplatelet adhesionen_US
dc.subjectprotein adhesionen_US
dc.subjectQuartz Tuning Forken_US
dc.subjectCompatibilityen_US
dc.subjectCoagulationen_US
dc.subjectMembraneen_US
dc.subjectFilmsen_US
dc.subjectPolymersen_US
dc.subjectTitaniumen_US
dc.subjectAdhesionen_US
dc.subjectRichen_US
dc.subjectPolymerizationen_US
dc.titlePlasma-Assisted Surface Modification and Heparin Immobilization: Dual-Functionalized Blood-Contacting Biomaterials With Improved Hemocompatibility and Antibacterial Featuresen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume10en_US
dc.identifier.issue6en_US
dc.authoridEROGUL, Osman/0000-0002-4640-6570-
dc.authoridMEYDAN, Ahmet Ersin/0000-0002-1425-0014-
dc.authoridOZGUZAR, Ferda Hatice/0000-0003-1205-6629-
dc.authoridKabay, Gozde/0000-0002-8594-3459-
dc.identifier.wosWOS:000897658000001en_US
dc.identifier.scopus2-s2.0-85143887212en_US
dc.institutionauthor-
dc.identifier.doi10.1002/admi.202202009-
dc.authorscopusid57201748273-
dc.authorscopusid55744584400-
dc.authorscopusid57195366182-
dc.authorscopusid56690594100-
dc.authorscopusid8711308500-
dc.authorscopusid12798821800-
dc.authorscopusid56247443100-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.2. Department of Biomedical Engineering-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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