Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/10344
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alangari, Mashari | - |
dc.contributor.author | Demir, Büsra | - |
dc.contributor.author | Akin Gültaktı, Çağlanaz | - |
dc.contributor.author | Ören, Ersin Emre | - |
dc.contributor.author | Hihath, Joshua | - |
dc.date.accessioned | 2023-04-16T10:01:15Z | - |
dc.date.available | 2023-04-16T10:01:15Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://doi.org/10.3390/biom13010129 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/10344 | - |
dc.description.abstract | DNA is an attractive material for a range of applications in nanoscience and nanotechnology, and it has recently been demonstrated that the electronic properties of DNA are uniquely sensitive to its sequence and structure, opening new opportunities for the development of electronic DNA biosensors. In this report, we examine the origin of multiple conductance peaks that can occur during single-molecule break-junction (SMBJ)-based conductance measurements on DNA. We demonstrate that these peaks originate from the presence of multiple DNA conformations within the solutions, in particular, double-stranded B-form DNA (dsDNA) and G-quadruplex structures. Using a combination of circular dichroism (CD) spectroscopy, computational approaches, sequence and environmental controls, and single-molecule conductance measurements, we disentangle the conductance information and demonstrate that specific conductance values come from specific conformations of the DNA and that the occurrence of these peaks can be controlled by controlling the local environment. In addition, we demonstrate that conductance measurements are uniquely sensitive to identifying these conformations in solutions and that multiple configurations can be detected in solutions over an extremely large concentration range, opening new possibilities for examining low-probability DNA conformations in solutions. | en_US |
dc.description.sponsorship | National Science Foundation [NSF-1807555/2036865] | en_US |
dc.description.sponsorship | This research was funded by National Science Foundation NSF-1807555/2036865 and from Quantum Biosystems Inc. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Biomolecules | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | single-molecule electronics | en_US |
dc.subject | molecular electronics | en_US |
dc.subject | single-molecule break junction | en_US |
dc.subject | DNA | en_US |
dc.subject | G-quadruplexes | en_US |
dc.subject | Circular-Dichroism | en_US |
dc.subject | G-Quadruplexes | en_US |
dc.subject | Quartet Structures | en_US |
dc.subject | Nucleic-Acids | en_US |
dc.subject | Cd Spectra | en_US |
dc.subject | Identification | en_US |
dc.subject | Water | en_US |
dc.subject | Long | en_US |
dc.title | Mapping DNA Conformations Using Single-Molecule Conductance Measurements | en_US |
dc.type | Article | en_US |
dc.department | TOBB ETÜ | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 1 | en_US |
dc.authorid | Demir, Busra/0000-0002-3911-2291 | - |
dc.authorid | Hihath, Joshua/0000-0002-2949-9293 | - |
dc.identifier.wos | WOS:000914975800001 | en_US |
dc.identifier.scopus | 2-s2.0-85146801220 | en_US |
dc.institutionauthor | … | - |
dc.identifier.pmid | 36671514 | en_US |
dc.identifier.doi | 10.3390/biom13010129 | - |
dc.authorwosid | Demir, Busra/W-1919-2018 | - |
dc.authorscopusid | 57204556287 | - |
dc.authorscopusid | 57204554850 | - |
dc.authorscopusid | 58075821500 | - |
dc.authorscopusid | 35846321000 | - |
dc.authorscopusid | 9436467600 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.2. Department of Biomedical Engineering | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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