Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/1038
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Demirkaya, K. | - |
dc.contributor.author | Can, Demirdöğen Birsen | - |
dc.contributor.author | Torun, Z. Öncel | - |
dc.contributor.author | Erdem, Onur | - |
dc.contributor.author | Çırak, E. | - |
dc.contributor.author | Tunca, Y. M. | - |
dc.date.accessioned | 2019-05-23T05:48:45Z | |
dc.date.available | 2019-05-23T05:48:45Z | |
dc.date.issued | 2017-10 | |
dc.identifier.citation | Demirkaya, K., Demirdöğen, B. C., Torun, Z. Ö., Erdem, O., Çırak, E., & Tunca, Y. M. (2017). Brain aluminium accumulation and oxidative stress in the presence of calcium silicate dental cements. Human & experimental toxicology, 36(10), 1071-1080. | en_US |
dc.identifier.issn | 0960-3271 | |
dc.identifier.other | number of pages 10 | |
dc.identifier.uri | https://doi.org/10.1177/0960327116679713 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/1038 | - |
dc.description.abstract | Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket. Rats were killed 7, 30 or 60 days after operation. Brain tissues were obtained before killing. Al levels were measured by atomic absorption spectrometry. Thiobarbituric acid reactive substances (TBARS) levels, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were determined using spectrophotometry. A transient peak was observed in brain Al level of MTA Angelus group on day 7, while MTA Fillapex and Theracal LC groups reached highest brain Al level on day 60. Brain TBARS level, CAT, SOD and GPx activities transiently increased on day 7 and then returned to almost normal levels. This in vivo study for the first time indicated that initial washout may have occurred in MTA Angelus, while element leaching after the setting is complete may have taken place for MTA Fillapex and Theracal LC. Moreover, oxidative stress was induced and antioxidant enzymes were transiently upregulated. Further studies to search for oxidative neuronal damage should be done to completely understand the possible toxic effects of calcium silicate cements on the brain. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.relation.ispartof | Human & Experimental Toxicology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | dental cement | en_US |
dc.subject | superoxide dismutase | en_US |
dc.subject | mineral trioxide aggregate | en_US |
dc.subject | glutathione peroxidase | en_US |
dc.subject | endodontics | en_US |
dc.subject | tbars | en_US |
dc.subject | catalase | en_US |
dc.subject | biomaterial | en_US |
dc.subject | aluminium | en_US |
dc.title | Brain Aluminium Accumulation and Oxidative Stress in the Presence of Calcium Silicate Dental Cements | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Biomedical Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 36 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1071 | |
dc.identifier.endpage | 1080 | |
dc.authorid | 0000-0002-1536-6123 | - |
dc.identifier.wos | WOS:000411222500009 | en_US |
dc.identifier.scopus | 2-s2.0-85029302417 | en_US |
dc.institutionauthor | Can Demirdöğen, Birsen | - |
dc.identifier.pmid | 27895098 | en_US |
dc.identifier.doi | 10.1177/0960327116679713 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.relation.other | Gulhane Military Medical Academy Research Project Fund [ARE-2013/39] | |
dc.identifier.scopusquality | Q2 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.2. Department of Biomedical Engineering | - |
Appears in Collections: | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
CORE Recommender
SCOPUSTM
Citations
11
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
18
checked on Dec 21, 2024
Page view(s)
134
checked on Dec 23, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.