Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10392
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dc.contributor.authorMutlu, O.-
dc.contributor.authorSalman, H.E.-
dc.contributor.authorAl-Thani, H.-
dc.contributor.authorEl-Menyar, A.-
dc.contributor.authorQidwai, U.A.-
dc.contributor.authorYalcin, H.C.-
dc.date.accessioned2023-04-16T10:02:13Z-
dc.date.available2023-04-16T10:02:13Z-
dc.date.issued2023-
dc.identifier.issn0010-4825-
dc.identifier.urihttps://doi.org/10.1016/j.compbiomed.2023.106609-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10392-
dc.description.abstractAn abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture, where the diameter of the aorta enlarges more than 50% of its normal diameter. The incidence rate of AAA has increased worldwide. Currently, about three out of every 100,000 people have aortic diseases. The diameter and geometry of AAAs influence the hemodynamic forces exerted on the arterial wall. Therefore, a reliable assessment of hemodynamics is crucial for predicting the rupture risk. Wall shear stress (WSS) is an important metric to define the level of the frictional force on the AAA wall. Excessive levels of WSS deteriorate the remodeling mechanism of the arteries and lead to abnormal conditions. At this point, WSS-related hemodynamic parameters, such as time-averaged WSS (TAWSS), oscillatory shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT) provide important information to evaluate the shear environment on the AAA wall in detail. Calculation of these parameters is not straightforward and requires a physical understanding of what they represent. In addition, computational fluid dynamics (CFD) solvers do not readily calculate these parameters when hemodynamics is simulated. This review aims to explain the WSS-derived parameters focusing on how these represent different characteristics of disturbed hemodynamics. A representative case is presented for spatial and temporal formulation that would be useful for interested researchers for practical calculations. Finally, recent hemodynamics investigations relating WSS-related parameters with AAA rupture risk assessment are presented. This review will be useful to understand the physical representation of WSS-related parameters in cardiovascular flows and how they can be calculated practically for AAA investigations. © 2023en_US
dc.description.sponsorshipNPRP13S-0108–200024; IRCC 2020-002; Qatar National Research Fund, QNRF; Qatar National Library, QNL; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 221M001en_US
dc.description.sponsorshipThis study is funded by Qatar University International Research Collaboration Co-Funds (IRCC) Program ( IRCC 2020-002 ) to HCY, Qatar National Research Fund (QNRF), National Priority Research Program ( NPRP13S-0108–200024 ) to HCY and OM, and TÜBİTAK (Scientific and Technological Research Council of Turkey) 3501 – Career Development Program (Project number: 221M001 ) to HES. The publication of this article was funded by the Qatar National Library.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofComputers in Biology and Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal aortic aneurysm (AAA)en_US
dc.subjectAneurysm rupture risk assessmenten_US
dc.subjectComputational fluid dynamics (CFD)en_US
dc.subjectEndothelial cell activation potential (ECAP)en_US
dc.subjectHemodynamicsen_US
dc.subjectOscillatory shear index (OSI)en_US
dc.subjectRelative residence time (RRT)en_US
dc.subjectTime average wall shear stress (TAWSS)en_US
dc.subjectBlood vesselsen_US
dc.subjectChemical activationen_US
dc.subjectComputational fluid dynamicsen_US
dc.subjectHealth risksen_US
dc.subjectHemodynamicsen_US
dc.subjectRisk assessmenten_US
dc.subjectShear stressen_US
dc.subjectAbdominal aortic aneurysmen_US
dc.subjectAbdominal aortic aneurysmsen_US
dc.subjectActivation potentialen_US
dc.subjectAneurysm ruptureen_US
dc.subjectAneurysm rupture risk assessmenten_US
dc.subjectCell activationen_US
dc.subjectComputational fluid dynamicen_US
dc.subjectEndothelial cell activation potentialen_US
dc.subjectEndothelial-cellsen_US
dc.subjectHaemodynamicsen_US
dc.subjectOscillatory shear indexen_US
dc.subjectRelative residence timeen_US
dc.subjectResidence timeen_US
dc.subjectRisks assessmentsen_US
dc.subjectRupture risken_US
dc.subjectTime average wall shear stressen_US
dc.subjectTime averagesen_US
dc.subjectWall shear stressen_US
dc.subjectWall-shear stressen_US
dc.subjectEndothelial cellsen_US
dc.subjectabdominal aortic aneurysmen_US
dc.subjectaneurysm ruptureen_US
dc.subjectblood flowen_US
dc.subjectcomputational fluid dynamicsen_US
dc.subjectendothelial cell activation potentialen_US
dc.subjectflow rateen_US
dc.subjecthemodynamic parametersen_US
dc.subjecthemodynamicsen_US
dc.subjecthumanen_US
dc.subjectoscillatory shear indexen_US
dc.subjectrelative residence timeen_US
dc.subjectReviewen_US
dc.subjectshear stressen_US
dc.subjecttime averaged wall shear stressen_US
dc.subjectbiological modelen_US
dc.subjectendothelium cellen_US
dc.subjectmechanical stressen_US
dc.subjectrisk assessmenten_US
dc.subjectAortic Aneurysm, Abdominalen_US
dc.subjectEndothelial Cellsen_US
dc.subjectHemodynamicsen_US
dc.subjectHumansen_US
dc.subjectModels, Cardiovascularen_US
dc.subjectRisk Assessmenten_US
dc.subjectStress, Mechanicalen_US
dc.titleHow Does Hemodynamics Affect Rupture Tissue Mechanics in Abdominal Aortic Aneurysm: Focus on Wall Shear Stress Derived Parameters, Time-Averaged Wall Shear Stress, Oscillatory Shear Index, Endothelial Cell Activation Potential, and Relative Residence Timeen_US
dc.typeReviewen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume154en_US
dc.identifier.wosWOS:000927319000001en_US
dc.identifier.scopus2-s2.0-85147020811en_US
dc.institutionauthor-
dc.identifier.pmid36724610en_US
dc.identifier.doi10.1016/j.compbiomed.2023.106609-
dc.authorscopusid57208480927-
dc.authorscopusid55567773400-
dc.authorscopusid15073996800-
dc.authorscopusid9943772800-
dc.authorscopusid6602234511-
dc.authorscopusid16306009400-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.scopusqualityQ1-
item.openairetypeReview-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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