Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10652
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dc.contributor.authorTaşkıran Sağ, Aslıhan-
dc.contributor.authorGüleryüz Kızıl, Pınar-
dc.contributor.authorYüce, Deniz-
dc.contributor.authorEroğlu, Erdal-
dc.date.accessioned2023-10-24T06:59:00Z-
dc.date.available2023-10-24T06:59:00Z-
dc.date.issued2023-
dc.identifier.issn1823-6138-
dc.identifier.urihttps://doi.org/10.54029/2023usk-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10652-
dc.description.abstractBackground & Objective: It is unknown whether occult neurological damage exists in mild COVID-19 patients. Obtaining direct histopathological evidence is difficult and often inappropriate. Radiological tools provide important clues regarding this issue. We aimed to investigate any overt or subtle changes in brain magnetic resonance (MR) scans of patients who recovered from non-severe COVID-19 at subacute stage. Methods: Cortical thicknesses/areas were measured in the olfactory bulb (OB), gyri recti, amygdalae, hippocampi, entorhinal cortices, perirhinal cortices, insulae, and substantia nigrae (SN) and compared with controls. Gross findings have also been reported. We assessed the correlations between radiological and clinical parameters. Results: Twenty percent of the patients had abnormal MR scans (mild ventriculomegaly, a hyperintense lesion, a lacune and hydrocephalus) although their relevance to COVID-19 was unknown. We found increased cortical thickness in bilateral OB, left entorhinal cortex, right perirhinal cortex, bilateral insulae, and bilateral gyri recti (p<0.05 for all). Right OB was thinner in patients with anosmia (p=0.015) and ageusia (p=0.004). Left perirhinal cortex and left gyrus rectus were thicker in patients with vertigo (p=0.040; p=0.032 respectively). Sleep disturbance was associated to increased thickness in left perirhinal cortex (p=0.033). Patients with brain fog had smaller SN bilaterally (right p=0.028 and left p=0.011). Patients with anxiety symptoms after COVID-19 had increased right hippocampal area(p=0.023). Neutrophil-to-lymphocyte ratio was correlated to the thickness of right perirhinal cortex (r=-0.57, p=0.02) while CRP, time since COVID-19 and age were not. Conclusion: These changes in limbic areas, insula and SN necessitate close monitoring of patients for autonomic complications, and secondary neurodegenerative processes.en_US
dc.language.isoenen_US
dc.publisherAsean Neurological Assocen_US
dc.relation.ispartofNeurology Asiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectcortical thicknessen_US
dc.subjectbrain fogen_US
dc.subjectinsulaen_US
dc.subjecthydrocephalusen_US
dc.subjectperirhinal cortexen_US
dc.subjectDeathen_US
dc.titleGrey Matter Analysis in Non-Severe Covid-19 Points Out Limbic-Related Cortex and Substantia Nigraen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume28en_US
dc.identifier.issue2en_US
dc.identifier.startpage307en_US
dc.identifier.endpage314en_US
dc.identifier.wosWOS:001027573300009en_US
dc.identifier.scopus2-s2.0-85167351438en_US
dc.institutionauthor-
dc.identifier.doi10.54029/2023usk-
dc.authorscopusid55982279000-
dc.authorscopusid57216852736-
dc.authorscopusid57514476300-
dc.authorscopusid7004662994-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ4-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
crisitem.author.dept03.14. Department of Internal Medicine-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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