Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10741
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dc.contributor.authorOzturk, S.-
dc.contributor.authorAytac, G.-
dc.contributor.authorKaradas, A.K.-
dc.contributor.authorDanisman, B.-
dc.contributor.authorTanriover, G.-
dc.contributor.authorDerin, N.-
dc.contributor.authorAkkoyunlu, G.-
dc.date.accessioned2023-10-24T07:01:52Z-
dc.date.available2023-10-24T07:01:52Z-
dc.date.issued2023-
dc.identifier.issn0003-2778-
dc.identifier.urihttps://doi.org/10.4103/jasi.jasi_144_21-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10741-
dc.description.abstractIntroduction: The cuprizone model is a well-established instance to study demyelination and remyelination in rodents. The primary aim of this study was to demonstrate the loss of function in motor activity. Second, it was evaluated together with the changes in the amount of myelin in the ongoing process. Materials and Methods: This study is based on the administration of the cuprizone model in male C57BL/6 mice by oral gavage. The advantage of the oral gavage model is that mice were subjected to the equal dose of cuprizone. For this reason, the nonequal in demyelination was minimized. We have designed four groups, including demyelination/control and remyelination/control. Results: The results of the walking test and open field test showed that locomotor activity in the demyelination group deteriorated. Increased glial fibrillary acidic protein and decreased myelin basic protein expressions were shown in the corpus callosum of the demyelination group compared to the control and remyelination groups. The g-ratio of the demyelination group was calculated 0.86 ± 0.07, the g-ratio of the demyelination control group was calculated 0.66 ± 0.1, the g-ratio of the remyelination group was calculated 0.83 ± 0.06, and the g-ratio of the remyelination control group was calculated 0.76 ± 0.09. Discussion and Conclusion: In conclusion, in this demyelination model, which was applied differently from the literature, in our study, the behavioral effect on motor activity and to what extent it appeared histologically was evaluated. Thus, investigating the loss of function in motor activity as well as histological examination increased the reliability of the model we created in our study. © 2023 Journal of the Anatomical Society of India.en_US
dc.description.sponsorshipAkdeniz Üniversitesi: TYL‑2016‑1552en_US
dc.description.sponsorshipThis study was supported by Akdeniz University Scientificen_US
dc.description.sponsorshipResearch Projects with project number TYL‑2016‑1552 and a Master of Science thesis of Serra OZTURK.en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of the Anatomical Society of Indiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimal modelen_US
dc.subjectcuprizoneen_US
dc.subjectdemyelinationen_US
dc.subjectoral gavageen_US
dc.subjectultrastructuralen_US
dc.titleDemonstration of the Decrease in Locomotor Activity and Central Nervous System in the Demyelination Model, in Which the Toxic Agent Is Realized by Gavageen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume72en_US
dc.identifier.issue1en_US
dc.identifier.startpage48en_US
dc.identifier.endpage57en_US
dc.identifier.wosWOS:001110369400016en_US
dc.identifier.scopus2-s2.0-85169506151en_US
dc.institutionauthor-
dc.identifier.doi10.4103/jasi.jasi_144_21-
dc.authorscopusid57189849635-
dc.authorscopusid57188768289-
dc.authorscopusid57222558291-
dc.authorscopusid57209225023-
dc.authorscopusid6507986489-
dc.authorscopusid6603384823-
dc.authorscopusid36648378700-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ4-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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