Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/10858
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Güney, Zeliha | - |
dc.contributor.author | Kurgan, Sivge | - |
dc.contributor.author | Önder, Canan | - |
dc.contributor.author | Tayman, Mahmure Ayse | - |
dc.contributor.author | Günhan, Oemer | - |
dc.contributor.author | Kantarcı, Alpdoğan | - |
dc.contributor.author | Serdar, Muhittin Abdülkadir | - |
dc.date.accessioned | 2023-12-23T06:06:33Z | - |
dc.date.available | 2023-12-23T06:06:33Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1432-6981 | - |
dc.identifier.issn | 1436-3771 | - |
dc.identifier.uri | https://doi.org/10.1007/s00784-023-05294-7 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/10858 | - |
dc.description.abstract | ObjectiveThis study aimed to evaluate the Wnt/beta-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis.Materials and methodsFifteen patients with stage III grade B (SIIIGB) and eleven with stage III grade C (SIIIGC) periodontitis were included and compared to 15 control subjects. beta-Catenin, Wnt 3a, Wnt 5a, and Wnt 10b expressions were evaluated by Q-PCR. Topographic localization of tissue beta-catenin, Wnt 5a, and Wnt 10b was measured by immunohistochemical analysis. TNF-alpha was used to assess the inflammatory state of the tissues, while Runx2 was used as a mediator of active destruction.ResultsWnt 3a, Wnt 5a, and Wnt 10b were significantly higher in gingival tissues in both grades of stage 3 periodontitis compared to the control group (p < 0.05). beta-Catenin showed intranuclear staining in connective tissue in periodontitis, while it was confined to intracytoplasmic staining in epithelial tissue and the cell walls in the control group. Wnt5a protein expression was elevated in periodontitis, with the most intense staining observed in the connective tissue of SIIIGC samples. Wnt10b showed the highest density in the connective tissue of patients with periodontitis.ConclusionsOur findings suggested that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway.Clinical RelevancePeriodontitis disrupts Wnt signaling in periodontal tissues in parallel with tissue inflammation and changes in morphology. This change in Wnt-related signaling pathways that regulate tissue homeostasis in the immunoinflammatory response may shed light on host-induced tissue destruction in the pathogenesis of the periodontal disease. | en_US |
dc.description.sponsorship | Ankara University Scientific Research Projects Office [17H0234001] | en_US |
dc.description.sponsorship | This research was supported by project 17H0234001 of the Ankara University Scientific Research Projects Office. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Heidelberg | en_US |
dc.relation.ispartof | Clinical Oral Investigations | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Periodontitis | en_US |
dc.subject | Wnt 3a | en_US |
dc.subject | Wnt 5a | en_US |
dc.subject | Wnt 10b | en_US |
dc.subject | beta-Catenin | en_US |
dc.subject | Gene-Expression | en_US |
dc.subject | Wnt/Beta-Catenin | en_US |
dc.subject | Wingless Homolog | en_US |
dc.subject | Beta-Catenin | en_US |
dc.subject | Bone | en_US |
dc.subject | Protein | en_US |
dc.subject | Cells | en_US |
dc.subject | Transcription | en_US |
dc.subject | Promotes | en_US |
dc.subject | Differentiation | en_US |
dc.title | Wnt Signaling in Periodontitis | en_US |
dc.type | Article | en_US |
dc.type | Article; Early Access | en_US |
dc.department | TOBB ETÜ | en_US |
dc.identifier.wos | WOS:001083277000001 | en_US |
dc.identifier.scopus | 2-s2.0-85173951606 | en_US |
dc.institutionauthor | … | - |
dc.identifier.pmid | 37814163 | en_US |
dc.identifier.doi | 10.1007/s00784-023-05294-7 | - |
dc.authorscopusid | 57211261371 | - |
dc.authorscopusid | 56038788400 | - |
dc.authorscopusid | 56611642000 | - |
dc.authorscopusid | 57204102774 | - |
dc.authorscopusid | 7005420259 | - |
dc.authorscopusid | 6603698171 | - |
dc.authorscopusid | 35591227100 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
item.openairetype | Article | - |
item.openairetype | Article; Early Access | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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