Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/11044
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Akcay, G. | - |
dc.contributor.author | Bahadir, A. | - |
dc.contributor.author | Tatar, Y. | - |
dc.contributor.author | Nuri, Atalar, M. | - |
dc.contributor.author | Babur, C. | - |
dc.contributor.author | Taylan, Ozkan, A. | - |
dc.date.accessioned | 2024-02-11T17:17:40Z | - |
dc.date.available | 2024-02-11T17:17:40Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://doi.org/10.1016/j.brainres.2024.148762 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/11044 | - |
dc.description.abstract | Toxoplasma gondii is a single-celled parasite that causes a disease called toxoplasmosis. It can reach the central nervous system, but the mechanism of T. gondii disrupting the functioning of these brain regions occurs in bradyzoite stage of parasite, causing brain damage by forming tissue cysts in brain. In our study, the effects of T. gondii on locomotor activity, anxiety, learning and memory, and norepinephrine (NE), levodopa (L-DOPA), dopamine (DA) and 3,4-D-dihydroxyphenylacetic acid (DOPAC) catecholamines in amygdala, striatum, prefrontal cortex and hippocampus regions of the brain were investigated in bradyzoite stage. Twenty male Albino mice Mus musculus, 4–5 weeks old, weighing 20–25 g, were used. T. gondii inoculated to mice intraperitonealy with 48–50-hour passages of T. gondii RH Ankara strain. For intraperitoneal inoculation of mice 5x104 tachyzoites per mouse. No inoculation was made in control group (n: 20). Locomotor activity behavior in open field test (OFT), anxious behavior in elevated plus maze (EPM), and learning behavior in novel object recognition (NOR) tests were evaluated. NE, L-DOPA, DA and DOPAC were measured by HPLC in brain tissues of amygdala, striatum, prefrontal cortex and hippocampus. A decrease was observed in the locomotor activity, anxiety and learning values of the T. gondii group compared to the control group (p < 0.05). The heighten in NE and L-DOPA levels in amygdala tissue of T. gondii group compared to control group, an elevation in NE, L-DOPA, DA and DOPAC levels in striatum tissue, and an increase in levels of NE in prefrontal cortex tissue were detected in monoamine results. In hippocampus tissue, an increase was observed in DA levels, while a decrease was observed in NE, L-DOPA and DOPAC levels. In our study, it has been shown that T. gondii in bradyzoite stage reduces locomotor activity, causes learning and memory impairment, and has anxiogenic effects. © 2024 Elsevier B.V. | en_US |
dc.description.sponsorship | School of Medicine, Duke University: 2021/09/03; Hitit Üniversitesi, HİTÜ: TIP19001.21.007 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Brain Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Bradyzoite | en_US |
dc.subject | Brain | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Learning and Memory | en_US |
dc.subject | Norepinephrine | en_US |
dc.subject | Toxoplasma gondii | en_US |
dc.subject | dihydroxyphenylacetic acid | en_US |
dc.subject | dopamine | en_US |
dc.subject | levodopa | en_US |
dc.subject | noradrenalin | en_US |
dc.subject | amygdala | en_US |
dc.subject | animal behavior | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | anxiety | en_US |
dc.subject | Article | en_US |
dc.subject | bradyzoite | en_US |
dc.subject | brain tissue | en_US |
dc.subject | controlled study | en_US |
dc.subject | corpus striatum | en_US |
dc.subject | elevated plus maze test | en_US |
dc.subject | hippocampal tissue | en_US |
dc.subject | hippocampus | en_US |
dc.subject | inoculation | en_US |
dc.subject | learning | en_US |
dc.subject | locomotion | en_US |
dc.subject | male | en_US |
dc.subject | memory | en_US |
dc.subject | mouse | en_US |
dc.subject | nonhuman | en_US |
dc.subject | novel object recognition test | en_US |
dc.subject | open field test | en_US |
dc.subject | prefrontal cortex | en_US |
dc.subject | Toxoplasma gondii | en_US |
dc.title | Investigation of the Effects of Toxoplasma Gondii on Behavioral and Molecular Mechanism in Bradyzoite Stage | en_US |
dc.type | Article | en_US |
dc.department | TOBB ETÜ | en_US |
dc.identifier.volume | 1828 | en_US |
dc.identifier.wos | WOS:001171054500001 | en_US |
dc.identifier.scopus | 2-s2.0-85183045396 | en_US |
dc.institutionauthor | … | - |
dc.identifier.pmid | 38228258 | en_US |
dc.identifier.doi | 10.1016/j.brainres.2024.148762 | - |
dc.authorscopusid | 57211125848 | - |
dc.authorscopusid | 9842576000 | - |
dc.authorscopusid | 57210943925 | - |
dc.authorscopusid | 57713720700 | - |
dc.authorscopusid | 6602101761 | - |
dc.authorscopusid | 24512412300 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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