Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/11073
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dc.contributor.authorCici, Mansur-
dc.contributor.authorDilmaç, Sayra-
dc.contributor.authorAytaç, Güneş-
dc.contributor.authorTanriover, Gamze-
dc.date.accessioned2024-03-09T15:12:37Z-
dc.date.available2024-03-09T15:12:37Z-
dc.date.issued2024-
dc.identifier.issn1052-0295-
dc.identifier.issn1473-7760-
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2305114-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/11073-
dc.description.abstractThree genes are associated with cerebral cavernous malformations (CCMs): CCM1, CCM2 and CCM3. These genes participate in microvascular angiogenesis, cell-to-cell junctions, migration and apoptosis. We evaluated the expression in vivo of CCM genes in primary tumors and metastastases in a murine model of metastatic breast carcinoma. We used cell lines obtained from metastasis of 4T1, 4TLM and 4THM breast cancer to liver and heart. These cells were injected into the mammary ridge of Balb/C female mice. After 27 days, the primary tumors, liver and lung were removed and CCM proteins were assessed using immunohistochemistry and western blot analysis. CCM proteins were expressed in primary tumor tissues of all tumor-injected animals; however, no CCM protein was expressed in metastatic tumor cells that migrated into other tissues. CCM proteins still were observed in the lung and liver tissue cells. Our findings suggest that CCM proteins are present during primary tumor formation, but when these cells develop metastatic potential, they lose CCM protein expression. CCM protein expression was lost or reduced in metastatic tissues compared to the primary tumor, which indicates that CCM proteins might participate in tumorigenesis and metastasis.en_US
dc.description.sponsorshipAkdeniz University Scientific Research Projects [TYL-2015-1036]en_US
dc.description.sponsorshipThis work was supported by the Akdeniz University Scientific Research Projects [TYL-2015-1036].en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectCCM1en_US
dc.subjectCCM2en_US
dc.subjectCCM3en_US
dc.subjectcerebral cavernous malformation proteinsen_US
dc.subjectmetastasisen_US
dc.subjectmiceen_US
dc.subjectSensory Neurons Promotesen_US
dc.subjectGene-Expressionen_US
dc.subjectCanceren_US
dc.subjectGrowthen_US
dc.subjectPdcd10en_US
dc.titleCerebral Cavernous Malformation Proteins, Ccm1, Ccm2 and Ccm3, Are Decreased in Metastatic Lesions in a Murine Breast Carcinoma Modelen_US
dc.typeArticleen_US
dc.typeArticle; Early Accessen_US
dc.departmentTOBB ETÜen_US
dc.authoridDILMAC, SAYRA/0000-0002-1080-6791-
dc.identifier.wosWOS:001154157600001en_US
dc.identifier.scopus2-s2.0-85183928229en_US
dc.institutionauthorAytaç, Güneş-
dc.identifier.pmid38293758en_US
dc.identifier.doi10.1080/10520295.2024.2305114-
dc.authorscopusid58861129100-
dc.authorscopusid55827694300-
dc.authorscopusid57188768289-
dc.authorscopusid6507986489-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.openairetypeArticle-
item.openairetypeArticle; Early Access-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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