Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/11172
Title: Recent Advances in Porous Nanomaterials-Based Drug Delivery Systems for Osteoarthritis
Authors: Çitoğlu, Senem
Duran, Hatice
Keywords: drug delivery systems (DDSs)
nanomaterials
osteoarthritis (OA)
porous materials
Publisher: Wiley-VCH GmbH, Weinheim
Source: Çitoğlu, S., & Duran, H. (2023). Recent advances in porous nanomaterials‐based drug delivery systems for osteoarthritis. Nano Select.
Abstract: Osteoarthritis (OA) is a common degenerative disease that develops over time, characterized mainly by inflammatory joints, cartilage deterioration, and ultimately loss of normal joint function. Some of the limitations that restrict the effectiveness of current OA treatment procedures include minimal penetration of medications into cartilage and lack of vascularity, leading to insufficient bioavailability and systemic toxicity. To increase the effectiveness of treatment, it is necessary to create novel non-invasive OA treatment techniques. Porous nanomaterials (PNMs) show great promise as sustained drug delivery systems (DDSs) due to their functionality, variable porosity, and high loading capacity. In addition, they can provide targeted drug delivery, facilitate controlled release of drugs, and prolong drug circulation and retention time while reducing adverse reactions and improving drug solubility. First, the current treatment methods and challenges are summarized. Subsequently, recent advances in DDSs for OA treatment based on PNMs with various pore sizes and structures are presented. Lastly, the parameters that affect the performance of DDSs are discussed by giving some suggestions for their design. The purpose of this review is to provide new insights into PNM-based DDS design and to inspire readers to adopt the smart design of intra-articular DDSs in the future.
URI: https://doi.org/10.1002/nano.202300099
https://hdl.handle.net/20.500.11851/11172
ISSN: 2688-4011
2688-4011
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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