Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/11172
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Çitoğlu, Senem | - |
dc.contributor.author | Duran, Hatice | - |
dc.date.accessioned | 2024-04-06T08:09:02Z | - |
dc.date.available | 2024-04-06T08:09:02Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Çitoğlu, S., & Duran, H. (2023). Recent advances in porous nanomaterials‐based drug delivery systems for osteoarthritis. Nano Select. | - |
dc.identifier.issn | 2688-4011 | - |
dc.identifier.issn | 2688-4011 | - |
dc.identifier.uri | https://doi.org/10.1002/nano.202300099 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/11172 | - |
dc.description.abstract | Osteoarthritis (OA) is a common degenerative disease that develops over time, characterized mainly by inflammatory joints, cartilage deterioration, and ultimately loss of normal joint function. Some of the limitations that restrict the effectiveness of current OA treatment procedures include minimal penetration of medications into cartilage and lack of vascularity, leading to insufficient bioavailability and systemic toxicity. To increase the effectiveness of treatment, it is necessary to create novel non-invasive OA treatment techniques. Porous nanomaterials (PNMs) show great promise as sustained drug delivery systems (DDSs) due to their functionality, variable porosity, and high loading capacity. In addition, they can provide targeted drug delivery, facilitate controlled release of drugs, and prolong drug circulation and retention time while reducing adverse reactions and improving drug solubility. First, the current treatment methods and challenges are summarized. Subsequently, recent advances in DDSs for OA treatment based on PNMs with various pore sizes and structures are presented. Lastly, the parameters that affect the performance of DDSs are discussed by giving some suggestions for their design. The purpose of this review is to provide new insights into PNM-based DDS design and to inspire readers to adopt the smart design of intra-articular DDSs in the future. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH GmbH, Weinheim | en_US |
dc.relation.ispartof | Nano Select | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | drug delivery systems (DDSs) | en_US |
dc.subject | nanomaterials | en_US |
dc.subject | osteoarthritis (OA) | en_US |
dc.subject | porous materials | en_US |
dc.title | Recent Advances in Porous Nanomaterials-Based Drug Delivery Systems for Osteoarthritis | en_US |
dc.type | Review | en_US |
dc.department | TOBB ETU Material Science and Nanotechnology Engineering | en_US |
dc.authorid | 0000-0001-6203-3906 | - |
dc.identifier.wos | WOS:001186480100001 | en_US |
dc.institutionauthor | Duran, Hatice | - |
dc.identifier.doi | 10.1002/nano.202300099 | - |
dc.relation.publicationcategory | Diğer | en_US |
item.openairetype | Review | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.6. Department of Material Science and Nanotechnology Engineering | - |
Appears in Collections: | Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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