Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/11559
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dc.contributor.authorMorgenstern, C.-
dc.contributor.authorLastres-Becker, I.-
dc.contributor.authorDemirdögen, B.C.-
dc.contributor.authorCosta, V.M.-
dc.contributor.authorDaiber, A.-
dc.contributor.authorForesti, R.-
dc.contributor.authorMotterlini, R.-
dc.date.accessioned2024-05-18T16:08:04Z-
dc.date.available2024-05-18T16:08:04Z-
dc.date.issued2024-
dc.identifier.issn2213-2317-
dc.identifier.urihttps://doi.org/10.1016/j.redox.2024.103134-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/11559-
dc.description.abstractThe cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of NRF2 levels, the modulation of NRF2 activity is typically determined by measuring changes in the expression of one or more of its target genes and/or the associated protein products. However, there is a lack of consensus regarding the most relevant set of these genes/proteins that best represents NRF2 activity across cell types and species. We present the findings of a comprehensive literature search that according to stringent criteria identifies GCLC, GCLM, HMOX1, NQO1, SRXN1 and TXNRD1 as a robust panel of markers that are directly regulated by NRF2 in multiple cell and tissue types. We assess the relevance of these markers in clinically accessible biofluids and highlight future challenges in the development and use of NRF2 biomarkers in humans. © 2024 The Authorsen_US
dc.description.sponsorshipEuropean Cooperation in Science and Technology, COST: CA20121; Medical Research Council, MRC: MR/X007413/1en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofRedox Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectNRF2en_US
dc.subjectOxidative stress responseen_US
dc.subjectTarget genesen_US
dc.subjectTranscription factoren_US
dc.subjectbiological markeren_US
dc.subjectglutamate cysteine ligaseen_US
dc.subjectglutamate cysteine ligase catalytic subuniten_US
dc.subjectglutamate cysteine ligase modifier subuniten_US
dc.subjectheme oxygenase 1en_US
dc.subjectnicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1en_US
dc.subjectreduced nicotinamide adenine dinucleotide phosphate dehydrogenaseen_US
dc.subjectsulfiredoxin 1en_US
dc.subjectthioredoxin reductase 1en_US
dc.subjecttranscription factor Nrf2en_US
dc.subjectunclassified drugen_US
dc.subjectbody fluiden_US
dc.subjectcell protectionen_US
dc.subjectGCLC geneen_US
dc.subjectGCLM geneen_US
dc.subjectgene targetingen_US
dc.subjectHMOX1 geneen_US
dc.subjecthumanen_US
dc.subjectnonhumanen_US
dc.subjectNQO1 geneen_US
dc.subjectNrf2 signalingen_US
dc.subjectoxidative stressen_US
dc.subjectprotein functionen_US
dc.subjectReviewen_US
dc.subjectSRXN1 geneen_US
dc.subjecttranslational researchen_US
dc.subjectTXNRD1 geneen_US
dc.titleBiomarkers of Nrf2 Signalling: Current Status and Future Challengesen_US
dc.typeReviewen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume72en_US
dc.identifier.wosWOS:001233628200001en_US
dc.identifier.scopus2-s2.0-85190738421en_US
dc.institutionauthor-
dc.identifier.doi10.1016/j.redox.2024.103134-
dc.authorscopusid58991850400-
dc.authorscopusid6603353572-
dc.authorscopusid58159606600-
dc.authorscopusid17134373000-
dc.authorscopusid7003754967-
dc.authorscopusid57206163750-
dc.authorscopusid7003812361-
dc.relation.publicationcategoryDiğeren_US
item.openairetypeReview-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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