Release Profile and in Vitro/In Vivo Studies on Bioengineered Bioactive Food Component-Loaded Electrospun Fibers and Electrosprayed Particles

Abstract

Electrospinning and electrospraying are promising methods of producing nanoparticles and nanofibers with high surface area-to-volume ratios. When these techniques are employed to produce bioactive food component (BFC)-loaded materials, several features that generally restrict their application, such as stability, loading capacity, low solubility, and bioavailability, can be conveniently improved. Such improvement maximizes their utilization in various application areas, particularly food engineering and health technologies. This chapter first explains the impact of different carrier-BFC formulations and process parameters on the features of engineered materials. Afterwards, an overview of kinetic models for understanding BFC release and the significance of in vitro/in vivo studies, which give valuable insights into their physiological interaction, cellular response, and therapeutic potential, are overviewed. Following a critical assessment of the advantages and disadvantages of each method, a perspective on up-and-coming techniques that can facilitate the large-scale development and preclinical evaluation of future bioengineered BFCs to facilitate their translational development is provided. © 2025 Elsevier Inc. All rights reserved.