Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/12540
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dc.contributor.authorGazi, Umut-
dc.contributor.authorColak, Bayram-
dc.contributor.authorTosun, Ozgur-
dc.contributor.authorSahin, Mustafa-
dc.contributor.authorUslu, Ugur-
dc.contributor.authorMumcuoglu, Kosta Y-
dc.contributor.authorTaylan-Ozkan, Aysegul-
dc.date.accessioned2025-07-10T19:45:10Z-
dc.date.available2025-07-10T19:45:10Z-
dc.date.issued2025-
dc.identifier.issn0969-0700-
dc.identifier.issn2052-2916-
dc.identifier.urihttps://doi.org/10.12968/jowc.2023.0186-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/12540-
dc.description.abstractObjective: This study aimed to investigate and compare the effects of maggot therapy (MT) and surgical debridement therapy (SDT) on the inflammatory phase of healing, a phase which does not favour tissue regeneration in hard-to-heal wounds. Method: SDT was performed in sterile operating theatre conditions. MT was applied with a dose of 5-7 maggots/cm(2). The levels of neutrophils, macrophages, M1 cells, M2 cells, T-cells and B-cells were analysed by using flow cytometry analysis which was performed on wound biopsy samples collected from hard-to-heal foot ulcers in patients with diabetes before and after either SDT or MT. Results: The experimental cohort comprised 25 patients. Patients in the MT group (n=13) demonstrated a shorter time to complete debridement, required fewer debridement sessions and had a higher rate of complete recovery than patients in the SDT group (n=12). Both therapies were able to reduce neutrophil, macrophage and M1 cell levels, and to elevate M2 cell, T-cell and B-cell frequencies. Statistically significantly higher variations were reported after MT than after SDT in neutrophil, M2 cell, T-cell and B-cell counts. Conclusion: The higher cell numbers detected in the MT group could be associated with an increased healing rate and reduced debridement time in comparison with SDT. MT not only debrided the wound effectively, but also positively influenced wound healing through its effect on the inflammatory process. Declaration of interest: Selcuk University Scientific Research Projects Coordination Unit, Konya, Turkey supported this study financially (grant number: 21401077). The authors have no conflicts of interest.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination Unit, Konya, Turkey [21401077]en_US
dc.description.sponsorshipAcknowledgements The authors thank Thorvacs, Ankara, Turkey for technical support and Selcuk University Scientific Research Projects Coordination Unit, Konya, Turkey for financial funding (grant number: 21401077) .en_US
dc.language.isoenen_US
dc.publisherMa Healthcare Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphocytesen_US
dc.subjectM2 Macrophagesen_US
dc.subjectMaggot Therapyen_US
dc.subjectNeutrophilsen_US
dc.subjectSurgical Debridementen_US
dc.subjectWounden_US
dc.subjectWound Careen_US
dc.subjectWound Dressingen_US
dc.subjectWound Healingen_US
dc.titleCutaneous Immune Cell Levels in Patients With Hard-To Wounds After Maggot Therapy and Surgical Debridement Therapyen_US
dc.typeArticleen_US
dc.departmentTOBB University of Economics and Technologyen_US
dc.identifier.volume34en_US
dc.identifier.issue6en_US
dc.identifier.wosWOS:001517492800005-
dc.identifier.scopus2-s2.0-105008719777-
dc.identifier.pmid40504398-
dc.identifier.doi10.12968/jowc.2023.0186-
dc.authorscopusid25959083300-
dc.authorscopusid54082986000-
dc.authorscopusid57213760909-
dc.authorscopusid7101877759-
dc.authorscopusid55926941900-
dc.authorscopusid35517383400-
dc.authorscopusid35517383400-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
dc.identifier.wosqualityQ3-
dc.description.woscitationindexScience Citation Index Expanded-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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