Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/12542
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kalmaz, Mekselina | - |
dc.contributor.author | Mungan, Semra | - |
dc.contributor.author | Demirdogen, Birsen Can | - |
dc.date.accessioned | 2025-07-10T19:45:10Z | - |
dc.date.available | 2025-07-10T19:45:10Z | - |
dc.date.issued | 2025 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.issn | 1559-1182 | - |
dc.identifier.uri | https://doi.org/10.1007/s12035-025-05027-9 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/12542 | - |
dc.description.abstract | Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder, with relapsing-remitting MS (RRMS) being the most common subtype. Interferon-gamma (IFN-gamma) plays a dual role in MS pathogenesis. MicroRNAs (miRNAs) have emerged as potential diagnostic biomarkers. This study examined the effect of relative expression of hsa-miR-24-3p and hsa-miR-181d-3p, plasma IFN-gamma levels, and the IFNG rs2069727 T/C variant on MS risk, evaluating their interrelationships and diagnostic potential. This case-control study comprised two overlapping groups-a genetic polymorphism group (330 RRMS, 330 healthy controls (HCs)) and a miRNA group (25 glatiramer acetate (GA)-treated RRMS patients, 25 treatment-na & iuml;ve RRMS patients, and 25 HCs)- collected at the Ankara Bilkent City Hospital Neurology Polyclinic. The IFNG rs2069727 T/C variant did not display a statistically significant disparity between RRMS patients and HCs. Significantly elevated hsa-miR-24-3p and hsa-miR-181d-3p relative expression levels were observed in GA-treated and treatment-na & iuml;ve RRMS patients compared to HCs. Conversely, age-adjusted plasma IFN-gamma concentrations were markedly lower in GA-treated and treatment-na & iuml;ve RRMS patients versus HCs. Individuals with low plasma IFN-gamma levels (<= 1.311 pg/mL) demonstrated significantly elevated hsa-miR-24-3p relative expression compared to the high IFN-gamma group (> 1.311 pg/mL). Conversely, subjects with low hsa-miR-181d-3p levels (<= 2.90) exhibited significantly higher plasma IFN-gamma concentrations relative to those with high hsa-miR-181d-3p levels (> 2.90). In the GA-treated group, EDSS negatively correlated with age-adjusted plasma IFN-gamma. This study identified age-adjusted plasma IFN-gamma, hsa-miR-24-3p, and hsa-miR-181d-3p expression as potential blood-based biomarkers for RRMS diagnosis and analyzed them alongside disability scores. The miRNAs in this study can be further evaluated as prospective therapeutic targets. | en_US |
dc.description.sponsorship | Turkiye Bilimsel ve Teknolojik Arastirma Kurumu [121S345] TUBITAK | en_US |
dc.description.sponsorship | The authors thank the subjects for their participation in this study. This study was supported by TUBITAK (121S345). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Multiple Sclerosis | en_US |
dc.subject | IFNG Rs2069727 T/C | en_US |
dc.subject | Interferon-Gamma | en_US |
dc.subject | Microrna | en_US |
dc.subject | Biomarker | en_US |
dc.title | Decoding the Potential Impact of Plasma hsa-miR and hsa-miR D-3p Expression, Plasma IFN-Γ Levels, and IFNG rs2069727 T/C Genetic Variant on Multiple Sclerosis Risk and Glatiramer Acetate Treatment | en_US |
dc.type | Article | en_US |
dc.department | TOBB University of Economics and Technology | en_US |
dc.identifier.wos | WOS:001500615300001 | - |
dc.identifier.scopus | 2-s2.0-105007110129 | - |
dc.identifier.pmid | 40457027 | - |
dc.identifier.doi | 10.1007/s12035-025-05027-9 | - |
dc.authorwosid | Mungan, Semra/Aar-3500-2021 | - |
dc.authorwosid | Can Demirdogen, Birsen/Aeq-0219-2022 | - |
dc.authorscopusid | 59925341500 | - |
dc.authorscopusid | 35722606900 | - |
dc.authorscopusid | 58159606600 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.identifier.wosquality | Q2 | - |
dc.description.woscitationindex | Science Citation Index Expanded | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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