Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/12542
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dc.contributor.authorKalmaz, Mekselina-
dc.contributor.authorMungan, Semra-
dc.contributor.authorDemirdogen, Birsen Can-
dc.date.accessioned2025-07-10T19:45:10Z-
dc.date.available2025-07-10T19:45:10Z-
dc.date.issued2025-
dc.identifier.issn0893-7648-
dc.identifier.issn1559-1182-
dc.identifier.urihttps://doi.org/10.1007/s12035-025-05027-9-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/12542-
dc.description.abstractMultiple sclerosis (MS) is an autoimmune neurodegenerative disorder, with relapsing-remitting MS (RRMS) being the most common subtype. Interferon-gamma (IFN-gamma) plays a dual role in MS pathogenesis. MicroRNAs (miRNAs) have emerged as potential diagnostic biomarkers. This study examined the effect of relative expression of hsa-miR-24-3p and hsa-miR-181d-3p, plasma IFN-gamma levels, and the IFNG rs2069727 T/C variant on MS risk, evaluating their interrelationships and diagnostic potential. This case-control study comprised two overlapping groups-a genetic polymorphism group (330 RRMS, 330 healthy controls (HCs)) and a miRNA group (25 glatiramer acetate (GA)-treated RRMS patients, 25 treatment-na & iuml;ve RRMS patients, and 25 HCs)- collected at the Ankara Bilkent City Hospital Neurology Polyclinic. The IFNG rs2069727 T/C variant did not display a statistically significant disparity between RRMS patients and HCs. Significantly elevated hsa-miR-24-3p and hsa-miR-181d-3p relative expression levels were observed in GA-treated and treatment-na & iuml;ve RRMS patients compared to HCs. Conversely, age-adjusted plasma IFN-gamma concentrations were markedly lower in GA-treated and treatment-na & iuml;ve RRMS patients versus HCs. Individuals with low plasma IFN-gamma levels (<= 1.311 pg/mL) demonstrated significantly elevated hsa-miR-24-3p relative expression compared to the high IFN-gamma group (> 1.311 pg/mL). Conversely, subjects with low hsa-miR-181d-3p levels (<= 2.90) exhibited significantly higher plasma IFN-gamma concentrations relative to those with high hsa-miR-181d-3p levels (> 2.90). In the GA-treated group, EDSS negatively correlated with age-adjusted plasma IFN-gamma. This study identified age-adjusted plasma IFN-gamma, hsa-miR-24-3p, and hsa-miR-181d-3p expression as potential blood-based biomarkers for RRMS diagnosis and analyzed them alongside disability scores. The miRNAs in this study can be further evaluated as prospective therapeutic targets.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [121S345] TUBITAKen_US
dc.description.sponsorshipThe authors thank the subjects for their participation in this study. This study was supported by TUBITAK (121S345).en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectIFNG Rs2069727 T/Cen_US
dc.subjectInterferon-Gammaen_US
dc.subjectMicrornaen_US
dc.subjectBiomarkeren_US
dc.titleDecoding the Potential Impact of Plasma hsa-miR and hsa-miR D-3p Expression, Plasma IFN-Γ Levels, and IFNG rs2069727 T/C Genetic Variant on Multiple Sclerosis Risk and Glatiramer Acetate Treatmenten_US
dc.typeArticleen_US
dc.departmentTOBB University of Economics and Technologyen_US
dc.identifier.wosWOS:001500615300001-
dc.identifier.scopus2-s2.0-105007110129-
dc.identifier.pmid40457027-
dc.identifier.doi10.1007/s12035-025-05027-9-
dc.authorwosidMungan, Semra/Aar-3500-2021-
dc.authorwosidCan Demirdogen, Birsen/Aeq-0219-2022-
dc.authorscopusid59925341500-
dc.authorscopusid35722606900-
dc.authorscopusid58159606600-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
dc.identifier.wosqualityQ2-
dc.description.woscitationindexScience Citation Index Expanded-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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