Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3249
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dc.contributor.authorGürbüz, Rumeysa Hekimoğlu-
dc.contributor.authorAtilla, Pergin-
dc.contributor.authorÖrgül, Gökçen-
dc.contributor.authorTanacan, Atakan-
dc.contributor.authorDolgun, Anıl-
dc.contributor.authorÇakar, Ayşe Nur-
dc.contributor.authorBeksaç, Mehmet Sinan-
dc.date.accessioned2019-12-30T07:28:20Z
dc.date.available2019-12-30T07:28:20Z
dc.date.issued2019
dc.identifier.citationGurbuz, R. H., Atilla, P., Orgul, G., Tanacan, A., Dolgun, A., Cakar, A. N., & Beksac, M. S. (2019). Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus. Fetal and pediatric pathology, 1-11.en_US
dc.identifier.issn1551-3815
dc.identifier.other11
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/15513815.2019.1600623-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3249-
dc.description.abstractObjective: To evaluate the impact of type-1 diabetes mellitus (DM) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on impaired placentation leading to early pregnancy loss. Methods: Miscarriage materials were obtained from eight pregnant women with type-1 DM without MTHFR polymorphism, eight with MTHFR polymorphisms without type-1 DM, and eight controls with neither DM nor MTHFR polymorphisms. Insulin-like growth factor-1 (IGF-1), leukemia inhibitory factor (LIF), and Beclin-1 expression were assessed to evaluate placentation. Results: Cytoplasmic LIF, IGF-1, and Beclin-1 expression were decreased in the superficial and glandular epithelial cells of the decidua in both study groups. LIF expression was increased in interstitial trophoblasts in the MTHFR group. IGF-1 expression was decreased in the decidual cells and interstitial trophoblasts in both study groups, while the decrease in stromal cells was noted only in type-1 DM group. Beclin-1 expression was increased in interstitial and villous trophoblasts in both study groups. Conclusion: The expression of IGF-1, LIF, and Beclin-1 are altered in both the decidua and the trophoblasts in pregnancies of women with type-1 DM and MTHFR polymorphisms, compared to normal pregnancies undergoing (elective) terminations.en_US
dc.description.sponsorshipThis study was supported by the Hacettepe University Research fund (Project no: 011D071010122012).
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofFETAL AND PEDIATRIC PATHOLOGYen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMTHFR gene polymorphismsen_US
dc.subjecttype 1 diabetes mellitusen_US
dc.subjectleukemia inhibitory factoren_US
dc.subjectinsulin like growth factor 1en_US
dc.subjectbeclin 1 proteinen_US
dc.titleImpaired Placentation and Early Pregnancy Loss in Patients With Mthfr Polymorphisms and Type-1 Diabetes Mellitusen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume38
dc.identifier.issue5
dc.identifier.startpage376
dc.identifier.endpage386
dc.authorid0000-0002-2585-7727-
dc.identifier.wosWOS:000469592400001en_US
dc.identifier.scopus2-s2.0-85063954211en_US
dc.institutionauthorÇakar, Ayşe Nur-
dc.identifier.pmid30955395en_US
dc.identifier.doi10.1080/15513815.2019.1600623-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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