A Method Comparison for D-Dimer Measurement

Abstract

OBJECTIVES:D-dimer is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. The determination of D-dimer concentration may help to diagnose thromboembolism. Its plasma value increases in pulmonary embolism, venous thrombosis and disseminated intravascular co¬agulation. While a negative result practically rules out thrombosis, a positive re¬sult can indicate thrombosis but does not rule out other potential causes. In this study, we compare immunoenzymatic Vidas D-Dimer Exclusion II (Vidas 3- Bio Merieoux) to tubidimetric STA- Liatest D-Dimer+ (StaCompact – Diagnostico Stago).MATERIALS and METHODS:Dimer levels were measured in 81 citrated plasma samples immediately and simultaneously in both devices. Statistical analysis was made by using SPSS 18 (SPSS Inc.,Chicago, IL).RESULTS:According to the One-Sample Kolmogorov-Smirnov Test the data were not normally distributed and there was no statistically significant difference between the two groups due to Wilcoxon Test (p>0,05).CONCLUSIONS:The data showed that the results of each method were compatible with each other.