Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3256
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dc.contributor.authorSakarya, Ahmet Hamdi-
dc.contributor.authorUzun, Hakan-
dc.contributor.authorTürkkanı, Ayten-
dc.contributor.authorÇakar, Ayşe Nur-
dc.contributor.authorHsieh, Yun-Huan-
dc.contributor.authorÜstün, Galip Gencay-
dc.contributor.authorŞafak, Tunç-
dc.date.accessioned2019-12-30T07:28:21Z
dc.date.available2019-12-30T07:28:21Z
dc.date.issued2019
dc.identifier.citationSakarya, A. H., Uzun, H., Türkkanı, A., Çakar, A. N., Hsieh, Y. H., Üstün, G. G., & Şafak, T. (2019). Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat. Journal of reconstructive microsurgery, 35(04), 244-253.en_US
dc.identifier.issn0743-684X
dc.identifier.other10
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1672130-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3256-
dc.description.abstractBackground The use of caffeine is not recommended prior to elective microsurgery due to its demonstrated negative effects on vessel anastomosis by the presumed sympathomimetic induction of vasoconstriction. In this study, we aimed to elucidate the systemic and local effects of caffeine on vessel diameter, anastomosis patency, and degree of intimal hyperplasia during the healing process. Methods Twenty-five rats were randomly assigned to five groups: (1) negative control, (2) preoperative systemic caffeine, (3) postoperative systemic caffeine, (4) perioperative systemic caffeine, and (5) a local caffeine group. Both the right and left femoral arteries were used. Ten anastomoses were performed per group. The arterial diameter was measured by micrometer, anastomosis patency was assessed surgically and histologically, and the histological examination was conducted 3 weeks postoperatively to determine intimal hyperplasia. Results The overall patency rate was 96%. Mild vasoconstriction was observed in the systemic caffeine groups (statistically insignificant); however, there were no negative effects on anastomosis patency. Local caffeine irrigation resulted in significant vasodilatation in the local caffeine group ( p =0.001); a similar effect was not observed in the other groups. There was a significant decrease in the intima/media ratio in the local caffeine group ( p <0.01), when compared with the control and systemic caffeine groups. No other intima/media ratio differences were observed among other comparison groups. Conclusion The systemic administration of caffeine, although statistically insignificant, has an observable effect on vasoconstriction. However, it does not appear to have negative effects on anastomosis patency regardless of its application period (pre-, post-, or perioperatively). The local application of caffeine resulted in considerable vasodilatation as opposed to the vasoconstriction effect in the systemic caffeine groups. Decreased intimal hyperplasia at the anastomosis edge, and antifibrotic properties in the surgical field were also observed in this group. Histologically, the local caffeine group demonstrated an additional beneficial effect on anastomosis remodeling.en_US
dc.language.isoenen_US
dc.publisherTHIEME MEDICAL PUBL INCen_US
dc.relation.ispartofJOURNAL OF RECONSTRUCTIVE MICROSURGERYen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeineen_US
dc.subjectanastomosis patencyen_US
dc.subjectintimal hyperplasiaen_US
dc.titleEffects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Raten_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume35
dc.identifier.issue4
dc.identifier.startpage244
dc.identifier.endpage253
dc.identifier.wosWOS:000466147000002en_US
dc.identifier.scopus2-s2.0-85065115467en_US
dc.institutionauthorÇakar, Ayşe Nur-
dc.identifier.pmid30231270en_US
dc.identifier.doi10.1055/s-0038-1672130-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.12. Department of Histology and Embryology-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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