Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6408
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dc.contributor.authorBaştuğ, Turgut-
dc.contributor.authorKuyucak, Serdar-
dc.date.accessioned2021-09-11T15:36:19Z-
dc.date.available2021-09-11T15:36:19Z-
dc.date.issued2011en_US
dc.identifier.citationBaştuğ, T., & Kuyucak, S. (2011). Comparative study of the energetics of ion permeation in Kv1. 2 and KcsA potassium channels. Biophysical journal, 100(3), 629-636.en_US
dc.identifier.issn0006-3495-
dc.identifier.issn1542-0086-
dc.identifier.urihttps://doi.org/10.1016/j.bpj.2010.12.3718-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6408-
dc.description.abstractBiological ion channels rely on a multi-ion transport mechanism for fast yet selective permeation of ions. The crystal structure of the KcsA potassium channel provided the first microscopic picture of this process. A similar mechanism is assumed to operate in all potassium channels, but the validity of this assumption has not been well investigated. Here, we examine The energetics of ion permeation in Shaker Kv1.2 and KcsA channels, which exemplify the six-transmembrane voltage-gated and two-transmembrane inward-rectifier channels. We study the feasibility of binding a third ion to the filter and the concerted motion of ions in the channel by constructing the potential of mean force for K+ ions in various configurations. For both channels, we find that a pair of K+ ions can move almost freely within the filter, but a relatively large free-energy barrier hinders the K+ ion from stepping outside the filter. We discuss the effect of the CMAP dihedral energy correction that was recently incorporated into the CHARMM force field on ion permeation dynamics.en_US
dc.description.sponsorshipAustralian Research CouncilAustralian Research Council; Turkish Scientific and Technical Research CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by grants from the Australian Research Council and the Turkish Scientific and Technical Research Council.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofBiophysical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleComparative Study of the Energetics of Ion Permeation in Kv1.2 and Kcsa Potassium Channelsen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Material Science and Nanotechnology Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümütr_TR
dc.identifier.volume100en_US
dc.identifier.issue3en_US
dc.identifier.startpage629en_US
dc.identifier.endpage636en_US
dc.authorid0000-0001-9123-9292-
dc.authorid0000-0003-4315-9532-
dc.identifier.wosWOS:000286957200013en_US
dc.identifier.scopus2-s2.0-79551667691en_US
dc.institutionauthorBaştuğ, Turgut-
dc.identifier.pmid21281577en_US
dc.identifier.doi10.1016/j.bpj.2010.12.3718-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.6. Department of Material Science and Nanotechnology Engineering-
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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