Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/6591
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DC Field | Value | Language |
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dc.contributor.author | Salman, Hüseyin Enes | - |
dc.contributor.author | Alser, Maha | - |
dc.contributor.author | Shekhar, Akshay | - |
dc.contributor.author | Gould, Russell A. | - |
dc.contributor.author | Benslimane, Fatiha M. | - |
dc.contributor.author | Butcher, Jonathan T. | - |
dc.contributor.author | Yalçın, Hüseyin C. | - |
dc.date.accessioned | 2021-09-11T15:42:55Z | - |
dc.date.available | 2021-09-11T15:42:55Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Salman, H. E., Alser, M., Shekhar, A., Gould, R. A., Benslimane, F. M., Butcher, J. T., & Yalcin, H. C. (2021). Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome. Biomechanics and Modeling in Mechanobiology, 20, 733-750. | en_US |
dc.identifier.issn | 1617-7959 | - |
dc.identifier.issn | 1617-7940 | - |
dc.identifier.uri | https://doi.org/10.1007/s10237-020-01413-5 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6591 | - |
dc.description.abstract | Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying genetic cause, suggesting that disturbed hemodynamics contribute to the embryonic development of these defects. Left atrial ligation (LAL) is a surgical procedure on embryonic chick resulting in a phenotype resembling clinical HLHS. In this study, we investigated disturbed hemodynamics and deteriorated cardiac growth following LAL to investigate possible mechanobiological mechanisms for the embryonic development of HLHS. We integrated techniques such as echocardiography, micro-CT and computational fluid dynamics (CFD) for these analyses. Specifically, LAL procedure causes an immediate flow disturbance over atrioventricular (AV) cushions. At later stages after the heart septation, it causes hemodynamic disturbances in LV. As a consequence of the LAL procedure, the left-AV canal and LV volume decrease in size, and in the opposite way, the right-AV canal and right ventricle volume increase. According to our CFD analysis, LAL results in an immediate decrease in the left AV canal WSS levels for 3.5-day (HH21) pre-septated hearts. For 7-day post-septated hearts (HH30), LAL leads to further reduction in WSS levels in the left AV canal, and relatively increased WSS levels in the right AV canal. This study demonstrates the critical importance of the disturbed hemodynamics during the heart valve and ventricle development. | en_US |
dc.description.sponsorship | Qatar National Research Fund (QNRF), National Priority Research Program [NPRP 10-0123-170222]; National Science Foundation (NSF), Civil, Mechanical and Manufacturing InnovationNational Science Foundation (NSF)NSF - Directorate for Engineering (ENG) [NSF CMMI 1635712]; Qatar National Library | en_US |
dc.description.sponsorship | This work was funded by Qatar National Research Fund (QNRF), National Priority Research Program (Grant Number NPRP 10-0123-170222) and National Science Foundation (NSF), Civil, Mechanical and Manufacturing Innovation (Grant Number NSF CMMI 1635712). The publication of this article was funded by the Qatar National Library. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Heidelberg | en_US |
dc.relation.ispartof | Biomechanics And Modeling In Mechanobiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Left atrial ligation | en_US |
dc.subject | Chick embryo | en_US |
dc.subject | Hypoplastic left heart syndrome | en_US |
dc.subject | Mitral valve | en_US |
dc.subject | Left ventricle | en_US |
dc.subject | Shear stress | en_US |
dc.subject | Embryonic heart development | en_US |
dc.subject | Computational fluid dynamics | en_US |
dc.subject | Hemodynamics | en_US |
dc.subject | Mechanobiology | en_US |
dc.title | Effect of Left Atrial Ligation-Driven Altered Inflow Hemodynamics on Embryonic Heart Development: Clues for Prenatal Progression of Hypoplastic Left Heart Syndrome | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Mechanical Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 733 | en_US |
dc.identifier.endpage | 750 | en_US |
dc.authorid | 0000-0002-9168-9987 | - |
dc.identifier.wos | WOS:000610040900002 | en_US |
dc.identifier.scopus | 2-s2.0-85099805881 | en_US |
dc.institutionauthor | Salman, Hüseyin Enes | - |
dc.identifier.pmid | 33481120 | en_US |
dc.identifier.doi | 10.1007/s10237-020-01413-5 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.7. Department of Mechanical Engineering | - |
Appears in Collections: | Makine Mühendisliği Bölümü / Department of Mechanical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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