Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6671
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKaya, İlkem Acar-
dc.contributor.authorGüner, Müberra Devrim-
dc.contributor.authorAkça, Gülçin-
dc.contributor.authorTunçbilek, Semra-
dc.contributor.authorAlhan, Aslıhan-
dc.contributor.authorTekeli, Emin-
dc.date.accessioned2021-09-11T15:43:08Z-
dc.date.available2021-09-11T15:43:08Z-
dc.date.issued2017en_US
dc.identifier.issn1682-024X-
dc.identifier.urihttps://doi.org/10.12669/pjms.332.11933-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6671-
dc.description.abstractObjective: Acinetobacter baumannii species cause nosocomial infections and can subsequently develop multidrug resistance (MDR). The objective of this study was to evaluate the susceptibility of A. baumannii to a novel combination of colistin and tigecycline, which may provide a faster and more efficacious treatment via a synergistic effect. Methods: We included 50 MDR A. baumannii samples that were isolated in our clinics between 2009 and 2014. We used broth microdilution (BMD) and the E-test to evaluate the effects of colistin and tigecycline, and the E-test to assess the interaction of the colistin-tigecycline combination. The interaction between the two antibiotics was evaluated using the fractional inhibition concentration (FIC) index and was classified as follows: FIC <= 1.0.5, synergistic; 0.5 < FIC < 1, partially synergistic; FIC=1, additive; 1 < FIC < 4, indifferent; and FIC >= 4, antagonistic. Results: No tigecycline and colistin resistance was determined by BMD or E-test. The interaction between colistin and tigecycline, when used in combination, was 2% synergistic, 6% additive, 88% indifferent, and 4% antagonistic. Conclusion: Although combination therapy is suggested for MDR A. baumannii infections, our results suggest that the synergistic effect of the colistin-tigecycline combination is insufficient to make it an optimal treatment choice.en_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectColistinen_US
dc.subjectMultidrug resistanceen_US
dc.subjectSynergyen_US
dc.subjectTigecyclineen_US
dc.titleEvaluation of the Synergistic Effect of a Combination of Colistin and Tigecycline Against Multidrug-Resistant Acinetobacter Baumanniien_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume33en_US
dc.identifier.issue2en_US
dc.identifier.startpage393en_US
dc.identifier.endpage397en_US
dc.authorid0000-0001-6982-9026-
dc.authorid0000-0001-6982-9026-
dc.identifier.wosWOS:000402357400029en_US
dc.identifier.scopus2-s2.0-85018524008en_US
dc.institutionauthorGüner, Müberra Devrim-
dc.identifier.pmid28523044en_US
dc.identifier.doi10.12669/pjms.332.11933-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

3
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

2
checked on Sep 21, 2024

Page view(s)

110
checked on Dec 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.