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https://hdl.handle.net/20.500.11851/6671
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaya, İlkem Acar | - |
dc.contributor.author | Güner, Müberra Devrim | - |
dc.contributor.author | Akça, Gülçin | - |
dc.contributor.author | Tunçbilek, Semra | - |
dc.contributor.author | Alhan, Aslıhan | - |
dc.contributor.author | Tekeli, Emin | - |
dc.date.accessioned | 2021-09-11T15:43:08Z | - |
dc.date.available | 2021-09-11T15:43:08Z | - |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 1682-024X | - |
dc.identifier.uri | https://doi.org/10.12669/pjms.332.11933 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6671 | - |
dc.description.abstract | Objective: Acinetobacter baumannii species cause nosocomial infections and can subsequently develop multidrug resistance (MDR). The objective of this study was to evaluate the susceptibility of A. baumannii to a novel combination of colistin and tigecycline, which may provide a faster and more efficacious treatment via a synergistic effect. Methods: We included 50 MDR A. baumannii samples that were isolated in our clinics between 2009 and 2014. We used broth microdilution (BMD) and the E-test to evaluate the effects of colistin and tigecycline, and the E-test to assess the interaction of the colistin-tigecycline combination. The interaction between the two antibiotics was evaluated using the fractional inhibition concentration (FIC) index and was classified as follows: FIC <= 1.0.5, synergistic; 0.5 < FIC < 1, partially synergistic; FIC=1, additive; 1 < FIC < 4, indifferent; and FIC >= 4, antagonistic. Results: No tigecycline and colistin resistance was determined by BMD or E-test. The interaction between colistin and tigecycline, when used in combination, was 2% synergistic, 6% additive, 88% indifferent, and 4% antagonistic. Conclusion: Although combination therapy is suggested for MDR A. baumannii infections, our results suggest that the synergistic effect of the colistin-tigecycline combination is insufficient to make it an optimal treatment choice. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Professional Medical Publications | en_US |
dc.relation.ispartof | Pakistan Journal of Medical Sciences | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acinetobacter baumannii | en_US |
dc.subject | Colistin | en_US |
dc.subject | Multidrug resistance | en_US |
dc.subject | Synergy | en_US |
dc.subject | Tigecycline | en_US |
dc.title | Evaluation of the Synergistic Effect of a Combination of Colistin and Tigecycline Against Multidrug-Resistant Acinetobacter Baumannii | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Internal Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 393 | en_US |
dc.identifier.endpage | 397 | en_US |
dc.authorid | 0000-0001-6982-9026 | - |
dc.authorid | 0000-0001-6982-9026 | - |
dc.identifier.wos | WOS:000402357400029 | en_US |
dc.identifier.scopus | 2-s2.0-85018524008 | en_US |
dc.institutionauthor | Güner, Müberra Devrim | - |
dc.identifier.pmid | 28523044 | en_US |
dc.identifier.doi | 10.12669/pjms.332.11933 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q3 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 03.14. Department of Internal Medicine | - |
Appears in Collections: | Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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