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https://hdl.handle.net/20.500.11851/6882
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kılıçay, Ebru | - |
dc.contributor.author | Karahaliloğlu, Zeynep | - |
dc.contributor.author | Alpaslan, Pınar | - |
dc.contributor.author | Hazer, Baki | - |
dc.contributor.author | Denkbaş, Emir Baki | - |
dc.date.accessioned | 2021-09-11T15:44:03Z | - |
dc.date.available | 2021-09-11T15:44:03Z | - |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.issn | 1568-5624 | - |
dc.identifier.uri | https://doi.org/10.1080/09205063.2017.1354670 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6882 | - |
dc.description.abstract | Antisense oligonucleotide (ASO)-conjugated--tocopherol succinate (TCS)-loaded-poly(lactic acid)-g-poly(ethylene glycol) nanoparticles (ASO-TCS-PLA-PEG NPs), with the ratio of polymer/TCS of 10:2.5, 10:5, 10:7 (w/w) were prepared for targeting cancer therapy. The amphiphilic PLA, amino terminated PEG graft copolymers were synthesized by ring opening polymerization reaction. Nanoparticles were produced by using double emulsion (w/o/w) solvent evaporation method. ASO-TCS-PLA-PEG NPs demonstrated satisfactory encapsulation and loading efficiency and size distribution. The short-term stability studies were carried out at 4 and 25 degrees C for 30days to assess their mean particle size, polydispersity index and zeta potential. The cellular uptake and extended cytoplasmic retention of the NPs in A549 human lung carcinoma and L929 mouse fibroblast cells were examined by fluorescence and confocal microscopy. In human lung cancer cells, ASO-TCS-PLA-PEG NPs exhibited better cellular internalization, cytotoxicity and apoptotic and necrotic effects compared to healthy cell line, L929. These findings showed that ASO-modified nanoparticles could serve as a promising nanocarrier for targeted tumor cells. | en_US |
dc.description.sponsorship | Bulent Ecevit UniversityBulent Ecevit University [BEU-2017-YKD-33496813-01] | en_US |
dc.description.sponsorship | This work was financially supported by Bulent Ecevit University [BEU-2017-YKD-33496813-01]. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.ispartof | Journal of Biomaterials Science-Polymer Edition | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | PLA-PEG | en_US |
dc.subject | antisense oligonucleotide | en_US |
dc.subject | -tocopherol succinate | en_US |
dc.subject | drug delivery | en_US |
dc.subject | human lung cancer cells | en_US |
dc.title | In Vitro Evaluation of Antisense Oligonucleotide Functionalized Core-Shell Nanoparticles Loaded With -Tocopherol Succinate | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Biomedical Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 15 | en_US |
dc.identifier.startpage | 1762 | en_US |
dc.identifier.endpage | 1785 | en_US |
dc.identifier.wos | WOS:000407503900010 | en_US |
dc.identifier.scopus | 2-s2.0-85025840222 | en_US |
dc.institutionauthor | Alpaslan, Pınar | - |
dc.identifier.pmid | 28696185 | en_US |
dc.identifier.doi | 10.1080/09205063.2017.1354670 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrenci | en_US |
dc.identifier.scopusquality | Q2 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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