Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/7282
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Öngürü, Önder | - |
dc.contributor.author | Düz, Bülent | - |
dc.contributor.author | Şimşek, Hakan | - |
dc.contributor.author | Günal, Armağan | - |
dc.contributor.author | Gönül, Engin | - |
dc.date.accessioned | 2021-09-11T15:56:14Z | - |
dc.date.available | 2021-09-11T15:56:14Z | - |
dc.date.issued | 2015 | en_US |
dc.identifier.issn | 0028-3843 | - |
dc.identifier.uri | https://doi.org/10.1016/j.pjnns.2015.05.003 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/7282 | - |
dc.description.abstract | Background: There are scarce data regarding the significance of the tumor size, hormonal activity and size of the pituitary tumor of the young; therefore, the study was designed to define the relation of the hormonal status of the large pituitary adenomas. Objective: We compared those features with tumors of the elderly (>40) with the young patients, and analyzed the clinicopathologic and proliferative features of pituitary macroadenomas in young adulthood (<= 40). Methods: 20-year archives of pituitary tumors in our clinics were reviewed and macroadenomas with diameter >= 3 cm were included in the study. We identified 46 pituitary adenomas and immunohistochemically stained them with pituitary hormones, p53 and Ki-67. Twenty-four cases were <= 40-year with an age range of 11-40 years (mean 28.0). Twenty-two cases were >40 with an age range of 44-78 years (mean 58.8). Results: In the young patient group, 15 (62.5%) were functional adenomas (6 prolactinomas, six growth hormone [GH], one adrenocorticotrophic hormone [ACTH] adenoma, two multi-hormonal [GH + ACTH]) and nine (37.5%) were either gonadotrophic or null cell adenomas. In the elderly group, five (22.7%) were functional adenomas (two adrenocorticotrophic hormone [ACTH] adenoma, one prolactinoma, one growth hormone [GH], one multihormonal [GH + ACTH]) and 17 (77.3%) were either gonadotrophic or null cell adenomas. Ki-67 proliferation index in adenomas of the young was approximately two-folds higher than the elderly (2.7% vs. 1.2%). Conclusion: In both groups, rare p53 positivity was identified. In conclusion, pituitary macroadenomas of the young show hormonal expression frequently with relatively high Ki-67 proliferation indices. (C)) 2015 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Termedia Publishing House Ltd | en_US |
dc.relation.ispartof | Neurologia I Neurochirurgia Polska | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Giant | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | Macroadenoma | en_US |
dc.subject | Pituitary adenoma | en_US |
dc.title | Pituitary macroadenomas (> 3 cm) in young adulthood: Pathologic and proliferative characteristics | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Surgical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 212 | en_US |
dc.identifier.endpage | 216 | en_US |
dc.identifier.wos | WOS:000358897900002 | en_US |
dc.identifier.scopus | 2-s2.0-84940101529 | en_US |
dc.institutionauthor | Gönül, Engin | - |
dc.identifier.pmid | 26188936 | en_US |
dc.identifier.doi | 10.1016/j.pjnns.2015.05.003 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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