Screening of Candidate Prognostic Biomarker Genes in Pediatric BCP-ALL

Abstract

Background/Objectives: BCP‐ALL (B‐cell precursor acute lymphoblastic leukemia) is characterized by recurring cytogenetic and molecular genetic abnormalities. We aimed to investigate recently identified genomic risk factors that affect the pathogenesis of BCP‐ALL, with effects on their molecular mechanism and prognostic significance by Next Generation Sequence (NGS) and gene expression analyses in childhood BCP‐ALL. The secondary aim of this study was to correlate the data obtained from study with some biological and clinical features as characteristic of pediatric BCP‐ALL patients, genetic aberrations and prognosis based on treatment protocol criteria.