Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7578
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSwiderski, Grzegorz-
dc.contributor.authorLazny, Ryszard-
dc.contributor.authorSienkiewicz, Michal-
dc.contributor.authorKalinowska, Monika-
dc.contributor.authorSwislocka, Renata-
dc.contributor.authorAcar, Ali Osman-
dc.contributor.authorLewandowski, Wlodzimierz-
dc.date.accessioned2021-09-11T15:57:59Z-
dc.date.available2021-09-11T15:57:59Z-
dc.date.issued2021en_US
dc.identifier.issn1996-1944-
dc.identifier.urihttps://doi.org/10.3390/ma14123274-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7578-
dc.description.abstractDacarbazine (DAC) 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide is an imidazole-carboxamide derivative that is structurally related to purines. DAC belongs to the triazene compounds, which are a group of alkylating agents with antitumor and mutagenic properties. DAC is a non-cell cycle specific drug, active in all phases of the cellular cycle. In the frame of this work the 3d metal complexes (cobalt and copper) with dacarbazine were synthesized. Their spectroscopic properties by the use of FT-IR, FT-Raman, and (HNMR)-H-1 were studied. The structures of dacarbazine and its complexes with copper(II) and cobalt(II) were calculated using DFT methods. The effect of metals on the electronic charge distribution of dacarbazine was discussed on the basis of calculated NBO atomic charges. The reactivity of metal complexes in relation to ligand alone was estimated on the basis of calculated energy of HOMO and LUMO orbitals. The aromaticity of the imidazole ring in dacarbazine and the complexes were compared (on the basis of calculated geometric indices of aromaticity). Thermal stability of the investigated 3d-metal complexes with dacarbazine and the products of their thermal decomposition were analyzed.en_US
dc.description.sponsorshipfunds for Science, Ministry of Science and Higher Education of Poland; Bialystok University of Technology [WZ/WB-IIS/5/2020]en_US
dc.description.sponsorshipStudies have been carried out in the framework of the work no. WZ/WB-IIS/5/2020 in Bialystok University of Technology and financed from the funds for Science, Ministry of Science and Higher Education of Poland.en_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMaterialsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdacarbazineen_US
dc.subjecttriazeneen_US
dc.subjectanticancer propertiesen_US
dc.subject3d metal complexesen_US
dc.subjectspectroscopy (IRen_US
dc.subjectRaman)en_US
dc.subjectNMRen_US
dc.titleSynthesis, Spectroscopic, and Theoretical Study of Copper and Cobalt Complexes With Dacarbazineen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Material Science and Nanotechnology Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümütr_TR
dc.identifier.volume14en_US
dc.identifier.issue12en_US
dc.identifier.wosWOS:000666725100001en_US
dc.identifier.scopus2-s2.0-85108740997en_US
dc.institutionauthorAcar, Ali Osman-
dc.identifier.pmid34199318en_US
dc.identifier.doi10.3390/ma14123274-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

WEB OF SCIENCETM
Citations

10
checked on Dec 21, 2024

Page view(s)

42
checked on Dec 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.