Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8332
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dc.contributor.authorSalman, Hüseyin Enes-
dc.contributor.authorYalçın, Hüseyin Çağatay-
dc.date.accessioned2022-01-15T13:02:33Z-
dc.date.available2022-01-15T13:02:33Z-
dc.date.issued2021-
dc.identifier.issn2308-3425-
dc.identifier.urihttps://doi.org/10.3390/jcdd8020014-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8332-
dc.description.abstractThe heart is the first functional organ in a developing embryo. Cardiac development continues throughout developmental stages while the heart goes through a serious of drastic morphological changes. Previous animal experiments as well as clinical observations showed that disturbed hemodynamics interfere with the development of the heart and leads to the formation of a variety of defects in heart valves, heart chambers, and blood vessels, suggesting that hemodynamics is a governing factor for cardiogenesis, and disturbed hemodynamics is an important source of congenital heart defects. Therefore, there is an interest to image and quantify the flowing blood through a developing heart. Flow measurement in embryonic fetal heart can be performed using advanced techniques such as magnetic resonance imaging (MRI) or echocardiography. Computational fluid dynamics (CFD) modeling is another approach especially useful when the other imaging modalities are not available and in-depth flow assessment is needed. The approach is based on numerically solving relevant physical equations to approximate the flow hemodynamics and tissue behavior. This approach is becoming widely adapted to simulate cardiac flows during the embryonic development. While there are few studies for human fetal cardiac flows, many groups used zebrafish and chicken embryos as useful models for elucidating normal and diseased cardiogenesis. In this paper, we explain the major steps to generate CFD models for simulating cardiac hemodynamics in vivo and summarize the latest findings on chicken and zebrafish embryos as well as human fetal hearts.en_US
dc.description.sponsorshipQatar National Research Fund (QNRF), National Priority Research Program [NPRP 10-0123-170222]en_US
dc.description.sponsorshipThis study was funded by Qatar National Research Fund (QNRF), National Priority Research Program (NPRP 10-0123-170222).en_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Cardiovascular Development and Diseaseen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmechanobiologyen_US
dc.subjectbiomechanicsen_US
dc.subjectcomputational fluid dynamicsen_US
dc.subjectfluid&#8211en_US
dc.subjectstructure interactionen_US
dc.subjectchicken embryoen_US
dc.subjectzebrafish embryoen_US
dc.subjectembryonic developmenten_US
dc.subjectcongenital heart defectsen_US
dc.subjecthuman fetal hearten_US
dc.subjectcardiogenesisen_US
dc.subjectZebrafishen_US
dc.titleComputational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Diseaseen_US
dc.typeReviewen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume8en_US
dc.identifier.issue2en_US
dc.authoridSalman, Huseyin Enes / 0000-0001-7572-9902-
dc.identifier.wosWOS:000622625400001en_US
dc.identifier.scopus2-s2.0-85101807860en_US
dc.institutionauthorSalman, Hüseyin Enes-
dc.identifier.pmid33572675en_US
dc.identifier.doi10.3390/jcdd8020014-
dc.authorwosidSalman, Huseyin Enes / AAV-6178-2021-
dc.authorscopusid55567773400-
dc.authorscopusid16306009400-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.scopusqualityQ1-
item.openairetypeReview-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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