Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8333
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dc.contributor.authorSalman, Hüseyin Enes-
dc.contributor.authorSaltık, Levent-
dc.contributor.authorYalçın, Hüseyin Çağatay-
dc.date.accessioned2022-01-15T13:02:33Z-
dc.date.available2022-01-15T13:02:33Z-
dc.date.issued2021-
dc.identifier.issn2311-5521-
dc.identifier.urihttps://doi.org/10.3390/fluids6080287-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8333-
dc.description.abstractCalcification and bicuspid valve formation are important aortic valve disorders that disturb the hemodynamics and the valve function. The detailed analysis of aortic valve hemodynamics would lead to a better understanding of the disease's etiology. We computationally modeled the aortic valve using simplified three-dimensional geometry and inlet velocity conditions obtained via echocardiography. We examined various calcification severities and bicuspid valve formation. Fluid-structure interaction (FSI) analyses were adapted using ANSYS Workbench to incorporate both flow dynamics and leaflet deformation accurately. Simulation results were validated by comparing leaflet movements in B-mode echo recordings. Results indicate that the biomechanical environment is significantly changed for calcified and bicuspid valves. High flow jet velocities are observed in the calcified valves which results in high transvalvular pressure difference (TPG). Wall shear stresses (WSS) increased with the calcification on both fibrosa (aorta side) and ventricularis (left ventricle side) surfaces of the leaflet. The WSS distribution is regular on the ventricularis, as the WSS values proportionally increase from the base to the tip of the leaflet. However, WSS patterns are spatially complex on the fibrosa side. Low WSS levels and spatially complex WSS patterns on the fibrosa side are considered as promoting factors for further calcification and valvular diseases.en_US
dc.description.sponsorshipQatar National Research Fund (QNRF), National Priority Research Program [NPRP 10-0123-170222, NPRP13S-0108-200024]; Qatar University International Research Collaboration Co-Fund (IRCC) program [IRCC-2020-002]; BARZAN HOLDINGSen_US
dc.description.sponsorshipThis study was funded by Qatar National Research Fund (QNRF), National Priority Research Program NPRP 10-0123-170222 and NPRP13S-0108-200024, and Qatar University International Research Collaboration Co-Fund (IRCC) program IRCC-2020-002. The publication of this article was covered with a generous support from BARZAN HOLDINGS.en_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofFluidsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcomputational fluid dynamicsen_US
dc.subjectfluid-structure interactionen_US
dc.subjectwall shear stressen_US
dc.subjecthemodynamicsen_US
dc.subjectcalcificationen_US
dc.subjectaortic valveen_US
dc.subjectFluid-Structure Interactionen_US
dc.subjectStructure Interaction-Modelen_US
dc.subjectFinite-Element-Analysisen_US
dc.subjectOf-The-Arten_US
dc.subjectHearten_US
dc.subjectCalcificationen_US
dc.subjectSimulationsen_US
dc.subjectDiseaseen_US
dc.subjectStrainen_US
dc.subjectFlowen_US
dc.titleComputational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves: Focus on Radial and Coaptation Patternsen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume6en_US
dc.identifier.issue8en_US
dc.authoridYalcin, huseyin C / 0000-0003-3825-9934-
dc.identifier.wosWOS:000689409700001en_US
dc.identifier.scopus2-s2.0-85114322364en_US
dc.institutionauthorSalman, Hüseyin Enes-
dc.identifier.doi10.3390/fluids6080287-
dc.authorscopusid55567773400-
dc.authorscopusid6602470854-
dc.authorscopusid16306009400-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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