Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8334
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dc.contributor.authorSalman, Hüseyin Enes-
dc.contributor.authorKamal, Reema Yousef-
dc.contributor.authorYalçın, Hüseyin Çağatay-
dc.date.accessioned2022-01-15T13:02:33Z-
dc.date.available2022-01-15T13:02:33Z-
dc.date.issued2021-
dc.identifier.issn1664-042X-
dc.identifier.urihttps://doi.org/10.3389/fphys.2021.731428-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8334-
dc.description.abstractFlow-driven hemodynamic forces on the cardiac tissues have critical importance, and have a significant role in the proper development of the heart. These mechanobiological mechanisms govern the cellular responses for the growth and remodeling of the heart, where the altered hemodynamic environment is believed to be a major factor that is leading to congenital heart defects (CHDs). In order to investigate the mechanobiological development of the normal and diseased hearts, identification of the blood flow patterns and wall shear stresses (WSS) on these tissues are required for an accurate hemodynamic assessment. In this study, we focus on the left heart hemodynamics of the human fetuses throughout the gestational stages. Computational fetal left heart models are created for the healthy fetuses using the ultrasound images at various gestational weeks. Realistic inflow boundary conditions are implemented in the models using the Doppler ultrasound measurements for resolving the specific blood flow waveforms in the mitral valve. Obtained results indicate that WSS and vorticity levels in the fetal left heart decrease with the development of the fetus. The maximum WSS around the mitral valve is determined around 36 Pa at the gestational week of 16. This maximum WSS decreases to 11 Pa at the gestational week of 27, indicating nearly three-times reduction in the peak shear stress. These findings reveal the highly dynamic nature of the left heart hemodynamics throughout the development of the human fetus and shed light into the relevance of hemodynamic environment and development of CHDs.en_US
dc.description.sponsorshipQatar National Research Fund (QNRF), National Priorities Research Program [NPRP 10-0123-170222]; Qatar National Libraryen_US
dc.description.sponsorshipThis study was funded by Qatar National Research Fund (QNRF), National Priorities Research Program (NPRP 10-0123-170222). The publication of this article was funded by the Qatar National Library.en_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Physiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcongenital heart defectsen_US
dc.subjectfetal heart analysisen_US
dc.subjectcomputational fluid dynamicsen_US
dc.subjectwall shear stressen_US
dc.subjecthemodynamicsen_US
dc.subjectmitral valveen_US
dc.subjectleft hearten_US
dc.subjectComputational Fluid-Dynamicsen_US
dc.subjectAbdominal Aortic-Aneurysmsen_US
dc.subjectWall Shear-Stressen_US
dc.subjectFlowen_US
dc.subjectVentriclesen_US
dc.subjectMechanicsen_US
dc.titleNumerical Investigation of the Fetal Left Heart Hemodynamics During Gestational Stagesen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume12en_US
dc.identifier.wosWOS:000698454500001en_US
dc.identifier.scopus2-s2.0-85115659260en_US
dc.institutionauthorSalman, Hüseyin Enes-
dc.identifier.pmid34566694en_US
dc.identifier.doi10.3389/fphys.2021.731428-
dc.authorscopusid55567773400-
dc.authorscopusid35169913600-
dc.authorscopusid16306009400-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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