Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/858
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bilgin, Esra | - |
dc.contributor.author | Can Demirdöğen, Birsen | - |
dc.contributor.author | Türkanoğlu Özçelik, Aysun | - |
dc.contributor.author | Demirkaya, Şeref | - |
dc.contributor.author | Adalı, Orhan | - |
dc.date.accessioned | 2019-03-27T07:20:24Z | |
dc.date.available | 2019-03-27T07:20:24Z | |
dc.date.issued | 2019-02-01 | |
dc.identifier.citation | Bilgin, E., Can Demirdöğen, B., Türkanoğlu Özçelik, A., Demirkaya, Ş., & Adalı, O. (2019). Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population. Neurological research, 41(2), 118-124. | en_US |
dc.identifier.issn | 0161-6412 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/858 | - |
dc.description.abstract | Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population. Methods: The genotypes and allele frequencies for 239 patients and 130 controls were determined by the PCR/RFLP method. No significant differences were found between patients and controls in terms of genotype and allele frequencies. Results: The frequency of the polymorphic ‘A’ allele was 0.358 in patients and 0.342 in controls for the C419A polymorphism in the GSTO1 gene. The frequency of the polymorphic ‘G’ allele for GSTO2 A424G SNP was 0.370 in patients and 0.404 in controls. The combined homozygous wild type genotype ‘CCAG’ was significantly higher in control group than in the patients. Conclusion: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. | en_US |
dc.description.sponsorship | Middle East Technical University Research Project Fund | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.relation.ispartof | Neurological Research | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | SNPs | en_US |
dc.subject | stroke | en_US |
dc.subject | ischemia | en_US |
dc.subject | Glutathione S transferase omega 2 | en_US |
dc.subject | Glutathione S transferase omega 1 | en_US |
dc.subject | Genetic polymorphism | en_US |
dc.title | Association Analysis of Glutathione S-Transferase Omega-1 and Omega-2 Genetic Polymorphisms and Ischemic Stroke Risk in a Turkish Population | en_US |
dc.type | Article | en_US |
dcterms.dateAccepted | 2018-10-31 | |
dc.department | Faculties, Faculty of Engineering, Department of Biomedical Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 41 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 118 | |
dc.identifier.endpage | 124 | |
dc.authorid | 0000-0002-1536-6123 | - |
dc.identifier.wos | WOS:000459561000003 | en_US |
dc.identifier.scopus | 2-s2.0-85057319092 | en_US |
dc.institutionauthor | Can Demirdöğen, Birsen | - |
dc.identifier.pmid | 30417762 | en_US |
dc.identifier.doi | 10.1080/01616412.2018.1544385 | - |
dc.identifier.doi | 10.1080/01616412.2018.1544385 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q2 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.2. Department of Biomedical Engineering | - |
Appears in Collections: | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Revised Manuscript.pdf | Full text | 156.27 kB | Adobe PDF | View/Open |
Revised Tables.pdf | Tables | 64.66 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
2
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
5
checked on Dec 21, 2024
Page view(s)
176
checked on Dec 23, 2024
Download(s)
98
checked on Dec 23, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.