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https://hdl.handle.net/20.500.11851/8660
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alser, Maha | - |
dc.contributor.author | Salman, Hüseyin Enes | - |
dc.contributor.author | Naija, Azza | - |
dc.contributor.author | Seers, Thomas Daniel | - |
dc.contributor.author | Khan, Talha | - |
dc.contributor.author | Yalcin, Huseyin Cagatay | - |
dc.date.accessioned | 2022-07-30T16:43:45Z | - |
dc.date.available | 2022-07-30T16:43:45Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Alser, M., Salman, H. E., Naïja, A., Seers, T. D., Khan, T., & Yalcin, H. C. (2022). Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo. Frontiers in Physiology, 499. | en_US |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | https://doi.org/10.3389/fphys.2022.849603 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/8660 | - |
dc.description.abstract | Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart's pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows. | en_US |
dc.description.sponsorship | Qatar National Research Fund (QNRF); National Priority Research Program [NPRP 10-0123-170222]; Qatar National Library | en_US |
dc.description.sponsorship | Funding This work was funded by Qatar National Research Fund (QNRF) and National Priority Research Program (Grant No. NPRP 10-0123-170222). Open Access funding was provided by the Qatar National Library. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media Sa | en_US |
dc.relation.ispartof | Frontiers In Physiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | congenital heart defects | en_US |
dc.subject | ventricle | en_US |
dc.subject | chick embryo | en_US |
dc.subject | right atrial ligation | en_US |
dc.subject | ultrasound | en_US |
dc.subject | micro-CT | en_US |
dc.subject | hemodynamics | en_US |
dc.subject | computational fluid dynamics | en_US |
dc.subject | Shear-Stress | en_US |
dc.subject | Morphogenesis | en_US |
dc.subject | Exposure | en_US |
dc.subject | Klf2 | en_US |
dc.title | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo | en_US |
dc.type | Article | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümü | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Mechanical Engineering | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.wos | WOS:000795578500001 | en_US |
dc.identifier.scopus | 2-s2.0-85138615936 | en_US |
dc.institutionauthor | Salman, Hüseyin Enes | - |
dc.identifier.pmid | 35492580 | en_US |
dc.identifier.doi | 10.3389/fphys.2022.849603 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.7. Department of Mechanical Engineering | - |
Appears in Collections: | Makine Mühendisliği Bölümü / Department of Mechanical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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