Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/8661
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Salman, Hüseyin Enes | - |
dc.contributor.author | Kamal, Reema Yousef | - |
dc.contributor.author | Hijazi, Ziyad M. | - |
dc.contributor.author | Yalcin, Huseyin Cagatay | - |
dc.date.accessioned | 2022-07-30T16:43:45Z | - |
dc.date.available | 2022-07-30T16:43:45Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Salman, H. E., Kamal, R. Y., Hijazi, Z. M., & Yalcin, H. C. (2022). Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts. Frontiers in Physiology, 13. | en_US |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | https://doi.org/10.3389/fphys.2022.856879 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/8661 | - |
dc.description.abstract | Congenital heart defects (CHDs) affect a wide range of societies with an incidence rate of 1.0-1.2%. These defects initiate at the early developmental stage and result in critical health disorders. Although genetic factors play a role in the formation of CHDs, the occurrence of cases in families with no history of CHDs suggests that mechanobiological forces may also play a role in the initiation and progression of CHDs. Hypoplastic left heart syndrome (HLHS) is a critical CHD, which is responsible for 25-40% of all prenatal cardiac deaths. The comparison of healthy and HLHS hearts helps in understanding the main hemodynamic differences related to HLHS. Echocardiography is the most common imaging modality utilized for fetal cardiac assessment. In this study, we utilized echocardiographic images to compare healthy and HLHS human fetal hearts for determining the differences in terms of heart chamber dimensions, valvular flow rates, and hemodynamics. The cross-sectional areas of chamber dimensions are determined from 2D b-mode ultrasound images. Valvular flow rates are measured via Doppler echocardiography, and hemodynamic quantifications are performed with the use of computational fluid dynamics (CFD) simulations. The obtained results indicate that cross-sectional areas of the left and right sides of the heart are similar for healthy fetuses during gestational development. The left side of HLHS heart is underdeveloped, and as a result, the hemodynamic parameters such as flow velocity, pressure, and wall shear stress (WSS) are significantly altered compared to those of healthy hearts. | en_US |
dc.description.sponsorship | Qatar National Research Fund (QNRF), National Priority Research Program [NPRP 10-0123-170222]; Qatar National Library | en_US |
dc.description.sponsorship | This study was funded by the Qatar National Research Fund (QNRF), National Priority Research Program (NPRP 10-0123-170222). Open access funding was provided by the Qatar National Library. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media Sa | en_US |
dc.relation.ispartof | Frontiers In Physiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | congenital heart defects | en_US |
dc.subject | fetal heart development | en_US |
dc.subject | hypoplastic left heart syndrome | en_US |
dc.subject | computational fluid dynamics | en_US |
dc.subject | tricuspid valve | en_US |
dc.subject | mitral valve | en_US |
dc.subject | disturbed hemodynamics | en_US |
dc.subject | echocardiography | en_US |
dc.subject | Computational Fluid-Dynamics | en_US |
dc.subject | In-Vivo | en_US |
dc.subject | Flow | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Ventricles | en_US |
dc.subject | Mechanics | en_US |
dc.title | Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts | en_US |
dc.type | Article | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümü | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Mechanical Engineering | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.wos | WOS:000780912800001 | en_US |
dc.identifier.scopus | 2-s2.0-85128211066 | en_US |
dc.institutionauthor | Salman, Hüseyin Enes | - |
dc.identifier.pmid | 35399257 | en_US |
dc.identifier.doi | 10.3389/fphys.2022.856879 | - |
dc.authorscopusid | 55567773400 | - |
dc.authorscopusid | 35169913600 | - |
dc.authorscopusid | 56583799700 | - |
dc.authorscopusid | 16306009400 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.7. Department of Mechanical Engineering | - |
Appears in Collections: | Makine Mühendisliği Bölümü / Department of Mechanical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
CORE Recommender
WEB OF SCIENCETM
Citations
6
checked on Dec 21, 2024
Page view(s)
100
checked on Dec 23, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.