Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/9105
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dc.contributor.authorZirh, Elham Bahador-
dc.contributor.authorKapakli, Elif Tasar-
dc.contributor.authorDolgun, Anil-
dc.contributor.authorUsubutun, Alp-
dc.contributor.authorZeybek, Naciye Dilara-
dc.date.accessioned2022-11-30T19:27:47Z-
dc.date.available2022-11-30T19:27:47Z-
dc.date.issued2022-
dc.identifier.issn0897-7194-
dc.identifier.issn1029-2292-
dc.identifier.urihttps://doi.org/10.1080/08977194.2022.2099849-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/9105-
dc.description.abstractOvarian cancer (OC) is clinically important because it is diagnosed late and has metastasis when it is diagnosed. Mortality risk increases 2.75 times in the presence of lymph node (LN) metastasis. During metastasis, many molecules including BMPs originated from stroma, and tumor cells participate through transcription factors and integrins for cytoskeleton regulation during cell migration. We hypothesized an inverse correlation between BMP2 and BMP7 along with changes in ZEB2, and integrin alpha 5 beta 1 in high-grade OCs in relation to LN metastasis. The BMP2 immunoreactivity was strong along with strong ZEB2 and weak integrins' immunoreactivity in samples with LN metastasis. Strong immunoreactivity of BMP7 was accompanied by strong immunoreactivity of integrins in the samples without LN metastasis. Study results showed BMP2's strong positive immunoreactivity and weak BMP7 immunoreactivity in tumor cells with a significantly weak inverse correlation. This inverse correlation should be considered as both BMPs have different effects in the window of cancer progression and invasion.en_US
dc.description.sponsorshipHacettepe University Scientific Research Unit [TSA-2017-13046]en_US
dc.description.sponsorshipOur work was supported by Hacettepe University Scientific Research Unit (TSA-2017-13046).en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGrowth Factorsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-grade ovarian canceren_US
dc.subjectlymph node metastasisen_US
dc.subjectBMP2en_US
dc.subjectBMP7en_US
dc.subjectintegrin alpha 5en_US
dc.subjectintegrin beta 1en_US
dc.subjectZEB2en_US
dc.subjectEpithelial-Mesenchymal Transitionen_US
dc.subjectCancer Cellsen_US
dc.subjectGene-Expressionen_US
dc.subjectBreast-Canceren_US
dc.subjectTgf-Betaen_US
dc.subjectBoneen_US
dc.subjectInhibitionen_US
dc.subjectProteinsen_US
dc.subjectSurvivalen_US
dc.titleThe Expression of Bmp, Integrin, Zeb2 in Ovarian High-Grade Serous Carcinoma in Relation With Lymph Node Metastasisen_US
dc.typeArticleen_US
dc.identifier.volume40en_US
dc.identifier.issue3.Nisen_US
dc.identifier.startpage153en_US
dc.identifier.endpage162en_US
dc.authoridBahador Zırh, Elham/0000-0002-6921-2365-
dc.authoridBarak Dolgun, Anil/0000-0002-2693-0666-
dc.identifier.wosWOS:000828976900001en_US
dc.identifier.scopus2-s2.0-85134610498en_US
dc.institutionauthorBahador Zirh, Elham-
dc.identifier.pmid35867635en_US
dc.identifier.doi10.1080/08977194.2022.2099849-
dc.authorwosidBahador Zırh, Elham/GWV-3753-2022-
dc.authorwosidBarak Dolgun, Anil/D-4235-2013-
dc.authorscopusid57223290462-
dc.authorscopusid57813058800-
dc.authorscopusid57812461300-
dc.authorscopusid6701379379-
dc.authorscopusid8540689700-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
dc.ozel2022v3_Editen_US
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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