Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/9139
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Erturk, Pinar Alpaslan | - |
dc.contributor.author | Altuntas, Sevde | - |
dc.contributor.author | Irmak, Gulseren | - |
dc.contributor.author | Buyukserin, Fatih | - |
dc.date.accessioned | 2022-11-30T19:33:20Z | - |
dc.date.available | 2022-11-30T19:33:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2576-6422 | - |
dc.identifier.uri | https://doi.org/10.1021/acsabm.2c00633 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/9139 | - |
dc.description.abstract | Collagen-based Sharpey's fibers are naturally located between alveolar bone and tooth, and they have critical roles in a well-functioning tooth such as mechanical stability, facile differentiation, and disease protection. The success of Sharpey's fibers in these important roles is due to their unique location, vertical alignment with respect to tooth surface, as well as their micronanofiber architecture. Inspired by these structures, herein, we introduce the use of nanoporous anodic aluminum oxide molds in a drop-casting setup to fabricate biopolymeric films possessing arrays of uniform Collagen: Gelatin (Col:Gel) nanopillars. Obtained structures have diameters of similar to 90 nm and heights of similar to 300 nm, yielding significantly higher surface roughness values compared to their flat counterparts. More importantly, the nanostructures were parallel to each other but perpendicular to the underlying film surface imitating the natural collagenous structures of Sharpey's fibers regarding nanoscale morphology, geometrical orientation, as well as biochemical content. Viability testing showed that the nanopillared Col:Gel films have high cell viabilities (over 90%), and they display significantly improved attachment (ca.similar to 2 times) and mineralization for Saos-2 cells when compared to flat Col:Gel films and Tissue Culture Polystyrene (TCPS) controls, plausibly due to their largely increased surface roughness and area. Hence, such Sharpey's fiber-inspired bioactive nanopillared Col:Gel films can be used as a dental implant coating material or tissue engineering platform with enhanced cellular and osteogenic properties. | en_US |
dc.description.sponsorship | Turkish Academy of Sciences (TUBA) | en_US |
dc.description.sponsorship | We thank Prof. Dr. Gokhan Demirel from Gazi University Chemistry Department for FTIR measurements. This study was supported by the Turkish Academy of Sciences (TUBA) . | en_US |
dc.language.iso | en | en_US |
dc.publisher | Amer Chemical Soc | en_US |
dc.relation.ispartof | ACS Applied Bio Materials | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Collagen-gelatin nanopillar | en_US |
dc.subject | Sharpey?s Fibers | en_US |
dc.subject | biomimetic | en_US |
dc.subject | osteogenic differentiation | en_US |
dc.subject | implant coating | en_US |
dc.subject | anodized alumina | en_US |
dc.subject | Mechanical-Properties | en_US |
dc.subject | Surface | en_US |
dc.subject | Gelatin | en_US |
dc.subject | Mineralization | en_US |
dc.subject | Attachment | en_US |
dc.subject | Nanofibers | en_US |
dc.subject | Osseointegration | en_US |
dc.subject | Biocompatibility | en_US |
dc.subject | Nanotopography | en_US |
dc.subject | Osteogenesis | en_US |
dc.title | Bioinspired Collagen/Gelatin Nanopillared Films as a Potential Implant Coating Material | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 4913 | en_US |
dc.identifier.endpage | 4921 | en_US |
dc.authorid | ALTUNTAS, SEVDE/0000-0002-4803-9479 | - |
dc.identifier.wos | WOS:000874685500001 | en_US |
dc.identifier.scopus | 2-s2.0-85139723019 | en_US |
dc.institutionauthor | Büyükserin, Fatih | - |
dc.identifier.pmid | 36203409 | en_US |
dc.identifier.doi | 10.1021/acsabm.2c00633 | - |
dc.authorwosid | ALTUNTAS, SEVDE/ABD-4898-2020 | - |
dc.authorscopusid | 57924968700 | - |
dc.authorscopusid | 56206354600 | - |
dc.authorscopusid | 56117379100 | - |
dc.authorscopusid | 12798821800 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.ozel | 2022v3_Edit | en_US |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.2. Department of Biomedical Engineering | - |
Appears in Collections: | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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