Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1399
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dc.contributor.authorCengiz, Cem-
dc.contributor.authorBulut, Şafak-
dc.contributor.authorBoyacıoğlu, A. Sedat-
dc.contributor.authorKuzu, M. Ayhan-
dc.date.accessioned2019-06-26T07:53:24Z
dc.date.available2019-06-26T07:53:24Z
dc.date.issued2017-08
dc.identifier.citationCengiz, C., Bulut, S., Boyacioglu, A. S., & Kuzu, M. A. (2017). Nerve/Glial antigen 2: A novel target for anti-tumor therapy in colorectal cancer. Digestion, 96(1), 60-66. doi:10.1159/000478853en_US
dc.identifier.issn0012-2823
dc.identifier.urihttps://www.karger.com/Article/FullText/478853-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1399-
dc.description.abstractBackground/Aims: To identify cell surface markers selectively expressed by tumor cells and tumor vasculature is the current goal for tumor therapy. One such marker is nerve/glial antigen 2 (NG2), which is a transmembrane glycoprotein. We aimed to investigate the expression of NG2 in colorectal cancer (CRC) and its association with clinicopathological parameters. Methods: Immunohistochemical staining of NG2, vascular endothelial growth factor, and CD34 in 65 patients diagnosed with CRC over a 5-year period was performed. NG2 expression in both tumor cells and tumor vasculature was scored according to the German Reactive Scoring System. The association between NG2 and patient and tumor characteristics was analyzed. Results: NG2 was expressed by tumor cells in 56.9%, tumor vasculature in 43%, and simultaneously by both in 27.6% of the cases. Tumor cell NG2 was more common in elderly patients (p = 0.023) and vascular NG2 was associated with better tumor differentiation (p = 0.035). Notably, vascular NG2 was expressed in half of the patients with left colon cancer, although it was not expressed in a majority of those with right colon cancer (50.9 vs. 17.7%, p = 0.041). Conclusion: Both tumor cell and vascular NG2 expression were shown to be present in a significant number of patients with CRC and this makes NG2 a double target for anti-tumor therapies. Such therapies might be more effective for elderly patients with well-differentiated left colon cancer. © 2017 S. Karger AG, Basel.en_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofDigestionen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve/glial antigen 2en_US
dc.subjectColorectal canceren_US
dc.subjectAngiogenesis inhibitorsen_US
dc.subjectTargeted tumor therapyen_US
dc.titleNerve-glial antigen 2: A novel target for anti-tumor therapy in colorectal canceren_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume96
dc.identifier.issue1
dc.identifier.startpage60
dc.identifier.endpage66
dc.authorid0000-0003-3233-8041-
dc.identifier.wosWOS:000407533500009en_US
dc.identifier.scopus2-s2.0-85025476816en_US
dc.institutionauthorCengiz, Cem-
dc.contributor.YOKid219000-
dc.identifier.pmid28715802en_US
dc.identifier.doi10.1159/000478853-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeArticle-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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