Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3220
Title: Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance
Authors: Çiftçiler, R.
Koluman, A.
Haznedaroğlu, İbrahim Celalettin
Akar, Nejat
258887
Keywords: Ankaferd blood stopper
gastrointestinal bleeding
Helicobacter pylori
Issue Date: 2019
Publisher: TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL
Source: Ciftciler, R., Koluman, A., Haznedaroglu, İ. C., & Akar, N. (2019). Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance. Turkish journal of medical sciences, 49(1), 347-355.
Abstract: Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, Istanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure. Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability. Strain 2 was isolated from a gastric ulcer patient and Strain 3 was isolated from a gastritis patient. 1% of ABS was added to all of the strains and antimicrobial susceptibility was observed on 30 and 60 min after application. Results: The efficacy of ABS solutions in achieving significant logarithmic reduction in foodborne pathogens of H. pylori was observed in this study. This study showed that ABS has antibacterial (Anti-H. pylori) effects. Conclusion: Our present study indicated, for the first time, that ABS could act against H. pylori. ABS is clinically used for the management of GI bleeding due to benign and malignant GI lesions. Thus, the possible anti-H. pylori effect of ABS shall expand the therapeutic spectrum of the drug in GI lesions in relation to H. pylori infection such as peptic ulser disease (PUD) and lymphoid tissue ( MALT) lymphomagenesis.
URI: http://journals.tubitak.gov.tr/medical/
https://hdl.handle.net/20.500.11851/3220
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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