Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3259
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dc.contributor.authorÖzlü, Büşra-
dc.contributor.authorErgin, Mert-
dc.contributor.authorBudak, Sevcan-
dc.contributor.authorTunalı, Selçuk-
dc.contributor.authorYıldırım, Nuh-
dc.contributor.authorErişken, Cevat-
dc.date.accessioned2019-12-30T07:28:21Z
dc.date.available2019-12-30T07:28:21Z
dc.date.issued2019
dc.identifier.citationOzlu, B., Ergin, M., Budak, S., Tunali, S., Yildirim, N., & Erisken, C. (2019). A bioartificial rat heart tissue: Perfusion decellularization and characterization. The International journal of artificial organs, 0391398819863434.en_US
dc.identifier.issn0391-3988
dc.identifier.other8
dc.identifier.urihttps://journals.sagepub.com/doi/full/10.1177/0391398819863434?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3259-
dc.description.abstractDespite remarkable advancement in the past decades, heart-related defects are still prone to progress irreversibly and can eventually lead to heart failure. A personalized extracellular matrix-based bioartificial heart created by allografts/xenografts emerges as an alternative as it can retain the original three-dimensional architecture combined with a preserved natural heart extracellular matrix. This study aimed at developing a procedure for decellularizing heart tissue harvested from rats and evaluating decellularization efficiency in terms of residual nuclear content and structural properties. Tissue sections showed no or little visible cell nuclei in decellularized heart, whereas the native heart showed dense cellularity. In addition, there was no significant variation in the alignment of muscle fibers upon decellularization. Furthermore, no significant difference was detected between native and decellularized hearts in terms of fiber diameter. Our findings demonstrate that fiber alignment and diameter can serve as additional parameters in the characterization of biological heart scaffolds as these provide valuable input for evaluating structural preservation of decellularized heart. The bioartificial scaffold formed here can be functionalized with patient's own material and utilized in regenerative engineering.en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ARTIFICIAL ORGANSen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWhole hearten_US
dc.subjectdecellularizationen_US
dc.subjectperfusionen_US
dc.subjectextracellular matrix structureen_US
dc.subjectfiber diameteen_US
dc.subjectfiber alignmenten_US
dc.titleA bioartificial rat heart tissue: Perfusion decellularization and characterizationen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume42
dc.identifier.issue12
dc.identifier.startpage757
dc.identifier.endpage764
dc.identifier.wosWOS:000477124800001en_US
dc.identifier.scopus2-s2.0-85070414443en_US
dc.institutionauthorTunalı, Selçuk-
dc.identifier.pmid31328608en_US
dc.identifier.doi10.1177/0391398819863434-
dc.authorwosidM-8113-2014-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.languageiso639-1en-
crisitem.author.dept03.14. Department of Internal Medicine-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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