Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3379
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dc.contributor.authorKoluman, Ahmet-
dc.contributor.authorAkar, Nejat-
dc.contributor.authorMalkan, Ümit Y.-
dc.contributor.authorHaznedaroğlu, İbrahim C.-
dc.date.accessioned2020-02-13T07:08:33Z-
dc.date.available2020-02-13T07:08:33Z-
dc.date.issued2016
dc.identifier.citationKoluman, A., Akar, N., Malkan, U. Y., & Haznedaroglu, I. C. (2016). Qualitative/chemical analyses of Ankaferd hemostat and its antioxidant content in synthetic gastric fluids. BioMed research international, 2016.en_US
dc.identifier.issn2314-6133
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3379-
dc.identifier.urihttps://www.hindawi.com/journals/bmri/2016/8957820/-
dc.description.abstractIntroduction. Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions. The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials. The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation. The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS. Methods. The pesticides were analyzed by GC-MS and LC-MS. The determination by ICP-MS after pressure digestion was performed for the heavy metals. HPLC was used for the detection of mycotoxins. Dioxin Response Chemically Activated Luciferase Gene Expression method was used for the dioxin evaluation. TOF-MS and spectra data were evaluated to detect the antioxidants and other molecules. Results. TOF-MS spectra revealed the presence of several antioxidant molecules (including tocotrienols, vitamin E, tryptophan, estriol, galangin, apigenin, oenin, 3,4-divanillyltetrahydrofuran, TBHQ, thymol, BHA, BHT, lycopene, glycyrrhetinic acid, and tomatine), which may have clinical implications in the pharmacobiological actions of ABS. Conclusion. The safety of ABS regarding the presence of heavy metals, pesticides, mycotoxins, GMO and dioxins, and PCBs was demonstrated. Thus the present toxicological results indicated the safety of ABS. The antioxidant content of ABS should be investigated in future studies.en_US
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofBioMed Research Internationalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemorrhageen_US
dc.subjecthemostaticsen_US
dc.subjectblood stopperen_US
dc.titleQualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluidsen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.authorid0000-0001-8228-8885-
dc.identifier.wosWOS:000369670100001en_US
dc.identifier.scopus2-s2.0-84958073903en_US
dc.institutionauthorAkar, Nejat-
dc.identifier.pmid26925418en_US
dc.identifier.doi10.1155/2016/8957820-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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