Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3682
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dc.contributor.authorVelioğlu, Zeynep Büşra-
dc.contributor.authorPulat, Deniz-
dc.contributor.authorDemirbakan, Beril-
dc.contributor.authorÖzcan, Burak-
dc.contributor.authorBayrak, Ece-
dc.contributor.authorErişken, Cevat-
dc.date.accessioned2020-09-17T14:43:36Z-
dc.date.available2020-09-17T14:43:36Z-
dc.date.issued2019-05-04
dc.identifier.citationVelioglu, Z. B., Pulat, D., Demirbakan, B., Ozcan, B., Bayrak, E., & Erisken, C. (2019). 3D-printed poly (lactic acid) scaffolds for trabecular bone repair and regeneration: scaffold and native bone characterization. Connective Tissue Research, 60(3), 274-282.en_US
dc.identifier.issn0300-8207
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3682-
dc.identifier.urihttps://doi.org/10.1080/03008207.2018.1499732-
dc.description.abstractPurpose: Study objectives were set to (i) fabricate 3D-printed scaffolds/grafts with varying pore sizes, (ii) characterize surface and mechanical properties of scaffolds, (iii) characterize biomechanical properties of bovine trabecular bone, and (iv) evaluate attachment and proliferation of human bone marrow mesenchymal stem cells on 3D-printed scaffolds. Materials and Methods: Poly(lactic acid) scaffolds were fabricated using 3D-printing technology, and characterized in terms of their surface as well as compressive mechanical properties. Trabecular bone specimens were obtained from bovine and characterized biomechanically under compression. Human bone marrow mesenchymal stem cells were seeded on the scaffolds, and their attachment capacity and proliferation were evaluated. Results: Contact angles and compressive moduli of scaffolds decreased with increasing pore dimensions of 0.5 mm, 1.0 mm, and 1.25 mm. Biomechanical characterization of trabecular bone yielded higher modulus values as compared to scaffolds with all pore sizes studied. Human bone marrow mesenchymal stem cells attached to the surfaces of all scaffolds yet proliferated more on scaffolds with 1.25 mm pore size. Conclusions: Collectively, given the similarity between 3D-printed scaffolds and native bone in terms of pore size, porosity, and appropriate mechanical properties of scaffolds, the 3D-printed poly(lactic acid) (PLA) scaffolds of this study appear as candidate substitutes for bone repair and regeneration.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofConnective Tissue Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D printingen_US
dc.subjectbiomechanicsen_US
dc.subjectbone regenerationen_US
dc.subjectscaffolden_US
dc.title3D-printed poly(lactic acid) scaffolds for trabecular bone repair and regeneration: scaffold and native bone characterizationen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume60
dc.identifier.issue3
dc.identifier.startpage274
dc.identifier.endpage282
dc.authorid0000-0002-6337-8022-
dc.identifier.wosWOS:000465125100007en_US
dc.identifier.scopus2-s2.0-85051928316en_US
dc.institutionauthorErişken, Cevat-
dc.identifier.pmid30058375en_US
dc.identifier.doi10.1080/03008207.2018.1499732-
dc.authorwosidP-7850-2014-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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