Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3780
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dc.contributor.authorÇalışkan, Hasan-
dc.contributor.authorAkat, Firat-
dc.contributor.authorTatar, Yakup-
dc.contributor.authorZaloğlu, Nezahet-
dc.contributor.authorDursun, Ali Doğan-
dc.contributor.authorBaştuğ, Metin-
dc.contributor.authorFıçıcılar, Hakan-
dc.date.accessioned2020-09-18T06:32:17Z-
dc.date.available2020-09-18T06:32:17Z-
dc.date.issued2019-10-30
dc.identifier.citationCaliskan, H., Akat, F., Tatar, Y., Zaloglu, N., Dursun, A. D., Bastug, M., & Ficicilar, H. (2019). Effects of exercise training on anxiety in diabetic rats. Behavioural brain research, 376, 112084.en_US
dc.identifier.issn0166-4328
dc.identifier.otherarticle number 112084, number of pages 10
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3780-
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2019.112084-
dc.description.abstractDiabetes mellitus (DM) is a common health problem, which manifests itself with chronic hyperglycemia and impaired insulin action. The prevalence of anxiety disorders tends to be high in the diabetic population. Exercise has a well-known anxiolytic effect, also demonstrated on rodents, but the effect of exercise on the DM-induced anxiety is still unknown. Female, Wistar albino rats were randomly divided into four groups (n=8) (C; EX; DM; DM+EX). DM was induced by injection (i.p.; 50 mg/kg) of Streptozotocin (STZ). Rats exercised in moderate intensity on the treadmill (15m/min; 5°; 30 min) for 5 weeks. Anxiety-like behavior (ALB) was evaluated by Open field test (OFT) and Elevated Plus Maze (EPM). According to OFT, central time and central entry have increased with in EX but not in DM+EX. There was no difference between C and DM. Central latency time didn't differ among groups. Unsupported rearing increased in both EX and DM+EX. There was no significant decrease in DM. Freezing time was significantly increased in the DM group. Exercise training reduced freezing time both in diabetic and non-diabetic animals. EPM results were similar. Time spent in open arm was increased significantly in exercise groups compared to their sedentary matches, and freezing time data were also parallel to OFT. Our study revealed that diabetes had shown an anxiogenic effect, which was not severe, and it only manifested itself on some behavioral parameters. Exercise training was reduced anxiety-like behavior both in diabetic and non-diabetic rats. However, because of the nature of exercise studies, it is hard to separate the anxiolytic effect of exercise from the alteration of locomotion.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectStreprozotocinen_US
dc.subjectAnxietyen_US
dc.subjectExerciseen_US
dc.subjectOpen field testen_US
dc.subjectElevated plus mazeen_US
dc.titleEffects of exercise training on anxiety in diabetic ratsen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume376
dc.identifier.wosWOS:000526056500015en_US
dc.identifier.scopus2-s2.0-85071963796en_US
dc.institutionauthorTatar, Yakup-
dc.identifier.pmid31356829en_US
dc.identifier.doi10.1016/j.bbr.2019.112084-
dc.authorscopusid57210943925-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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