Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6667
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKayıran, Oğuz-
dc.contributor.authorCüzdan, Suat Sedat-
dc.contributor.authorUysal, Afşin-
dc.contributor.authorKoçer, Uğur-
dc.date.accessioned2021-09-11T15:43:07Z-
dc.date.available2021-09-11T15:43:07Z-
dc.date.issued2017en_US
dc.identifier.issn0971-5916-
dc.identifier.urihttps://doi.org/10.4103/ijmr.IJMR_1428_14-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6667-
dc.description.abstractBackground & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings.en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthyl pyruvateen_US
dc.subjectischaemiaen_US
dc.subjectreperfusion injuryen_US
dc.subjectskin flapen_US
dc.titleEthyl pyruvate improves skin flap survival after ischaemia reperfusion injuryen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.identifier.volume146en_US
dc.identifier.startpage369en_US
dc.identifier.endpage374en_US
dc.identifier.wosWOS:000423277900012en_US
dc.institutionauthorUysal, Afşin-
dc.identifier.pmid29355144en_US
dc.identifier.doi10.4103/ijmr.IJMR_1428_14-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

WEB OF SCIENCETM
Citations

3
checked on Mar 9, 2024

Page view(s)

20
checked on Mar 25, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.