Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6882
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKılıçay, Ebru-
dc.contributor.authorKarahaliloğlu, Zeynep-
dc.contributor.authorAlpaslan, Pınar-
dc.contributor.authorHazer, Baki-
dc.contributor.authorDenkbaş, Emir Baki-
dc.date.accessioned2021-09-11T15:44:03Z-
dc.date.available2021-09-11T15:44:03Z-
dc.date.issued2017en_US
dc.identifier.issn0920-5063-
dc.identifier.issn1568-5624-
dc.identifier.urihttps://doi.org/10.1080/09205063.2017.1354670-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6882-
dc.description.abstractAntisense oligonucleotide (ASO)-conjugated--tocopherol succinate (TCS)-loaded-poly(lactic acid)-g-poly(ethylene glycol) nanoparticles (ASO-TCS-PLA-PEG NPs), with the ratio of polymer/TCS of 10:2.5, 10:5, 10:7 (w/w) were prepared for targeting cancer therapy. The amphiphilic PLA, amino terminated PEG graft copolymers were synthesized by ring opening polymerization reaction. Nanoparticles were produced by using double emulsion (w/o/w) solvent evaporation method. ASO-TCS-PLA-PEG NPs demonstrated satisfactory encapsulation and loading efficiency and size distribution. The short-term stability studies were carried out at 4 and 25 degrees C for 30days to assess their mean particle size, polydispersity index and zeta potential. The cellular uptake and extended cytoplasmic retention of the NPs in A549 human lung carcinoma and L929 mouse fibroblast cells were examined by fluorescence and confocal microscopy. In human lung cancer cells, ASO-TCS-PLA-PEG NPs exhibited better cellular internalization, cytotoxicity and apoptotic and necrotic effects compared to healthy cell line, L929. These findings showed that ASO-modified nanoparticles could serve as a promising nanocarrier for targeted tumor cells.en_US
dc.description.sponsorshipBulent Ecevit UniversityBulent Ecevit University [BEU-2017-YKD-33496813-01]en_US
dc.description.sponsorshipThis work was financially supported by Bulent Ecevit University [BEU-2017-YKD-33496813-01].en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Biomaterials Science-Polymer Editionen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPLA-PEGen_US
dc.subjectantisense oligonucleotideen_US
dc.subject-tocopherol succinateen_US
dc.subjectdrug deliveryen_US
dc.subjecthuman lung cancer cellsen_US
dc.titleIn vitro evaluation of antisense oligonucleotide functionalized core-shell nanoparticles loaded with -tocopherol succinateen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume28en_US
dc.identifier.issue15en_US
dc.identifier.startpage1762en_US
dc.identifier.endpage1785en_US
dc.identifier.wosWOS:000407503900010en_US
dc.identifier.scopus2-s2.0-85025840222en_US
dc.institutionauthorAlpaslan, Pınar-
dc.identifier.pmid28696185en_US
dc.identifier.doi10.1080/09205063.2017.1354670-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

WEB OF SCIENCETM
Citations

3
checked on Mar 9, 2024

Page view(s)

30
checked on Mar 25, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.