Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7575
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dc.contributor.authorGürlek, Ayşe Cansu-
dc.contributor.authorSevinc, Burcu-
dc.contributor.authorBayrak, Ece-
dc.contributor.authorErişken, Cevat-
dc.date.accessioned2021-09-11T15:57:58Z-
dc.date.available2021-09-11T15:57:58Z-
dc.date.issued2017en_US
dc.identifier.issn0928-4931-
dc.identifier.issn1873-0191-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.10.071-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7575-
dc.description.abstractAnterior cruciate ligament (ACL) is the most frequently torn ligament in the knee, and complete healing is unlikely due to lack of vascularization. Current approaches for the treatment of ACL injuries include surgical interventions and grafting, however recent reports show that surgeries have 94% recurrency, and that repaired tissues are biomechanically inferior to the native tissue. These necessitate the need for new strategies for scar-free repair/regeneration of ACL injuries. Polycaprolactone (PCL) is a biodegradable and biocompatible synthetic polymer, which has been widely used in the connective tissue repair/regeneration attempts. Here, we report on the synthesis of PCL via ring opening polymerization using epsilon-caprolactone as the monomer, and ammonium heptamolybdate as a catalyst. The synthesized PCL was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. It was then processed using electrospinning to form nanofiber-based scaffolds. These scaffolds were characterized in terms of surface as well as mechanical properties, and compared to the properties of commercially available PCL, and of native ACL tissue harvested from sheep. In addition, scaffolds fabricated with synthesized PCL were evaluated regarding their cell attachment capacity using human bone marrow mesenchymal stem cells (hBMSCs). Our findings demonstrated that the synthesized PCL is similar to its commercially available counterpart in terms of surface morphology and mechanical properties. In addition, fibrous scaffolds generated with electrospinning showed weaker mechanical properties visa vis native ACL tissue in terms of ultimate stress, and elastic modulus. Also, the synthesized PCL can accommodate cell attachment when tested with hBMSCs. Putting together, these observations reveal that the PCL synthesized in this study could be a good candidate as a biomaterial for ligament repair or regeneration. (C) 2010 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycaprolactoneen_US
dc.subjectSynthesisen_US
dc.subjectAnterior cruciate ligamenten_US
dc.subjectBiomechanicsen_US
dc.subjectTissue engineeringen_US
dc.titleSynthesis and characterization of polycaprolactone for anterior cruciate ligament regenerationen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume71en_US
dc.identifier.startpage820en_US
dc.identifier.endpage826en_US
dc.authorid0000-0002-6337-8022-
dc.authorid0000-0002-3460-1942-
dc.identifier.wosWOS:000390967200096en_US
dc.identifier.scopus2-s2.0-85005814218en_US
dc.institutionauthorGürlek, Ayşe Cansu-
dc.institutionauthorSevinc, Burcu-
dc.institutionauthorBayrak, Ece-
dc.institutionauthorErişken, Cevat-
dc.identifier.pmid27987777en_US
dc.identifier.doi10.1016/j.msec.2016.10.071-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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