Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7650
Title: The importance of studying inherited hematological disorders in ancient Anatolian populations
Authors: Alakoc, Yesim Doğan
Akar, Nejat
Keywords: DNA
population genetics
molecular anthropology
factor V G1691A (Leiden)
betathalassemia
sickle cell anemia
Anatolia
Issue Date: 2011
Publisher: Galenos Yayincilik
Abstract: Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL. mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns. (Turk J Hematol 2011; 28: 257-63)
URI: https://doi.org/10.5152/tjh.2011.43
https://hdl.handle.net/20.500.11851/7650
ISSN: 1300-7777
1308-5263
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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