Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7650
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dc.contributor.authorAlakoc, Yesim Doğan-
dc.contributor.authorAkar, Nejat-
dc.date.accessioned2021-09-11T15:58:33Z-
dc.date.available2021-09-11T15:58:33Z-
dc.date.issued2011en_US
dc.identifier.issn1300-7777-
dc.identifier.issn1308-5263-
dc.identifier.urihttps://doi.org/10.5152/tjh.2011.43-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7650-
dc.description.abstractBefore analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL. mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns. (Turk J Hematol 2011; 28: 257-63)en_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNAen_US
dc.subjectpopulation geneticsen_US
dc.subjectmolecular anthropologyen_US
dc.subjectfactor V G1691A (Leiden)en_US
dc.subjectbetathalassemiaen_US
dc.subjectsickle cell anemiaen_US
dc.subjectAnatoliaen_US
dc.titleThe importance of studying inherited hematological disorders in ancient Anatolian populationsen_US
dc.typeReviewen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume28en_US
dc.identifier.issue4en_US
dc.identifier.startpage257en_US
dc.identifier.endpage263en_US
dc.authorid0000-0001-6650-6133-
dc.identifier.wosWOS:000297962900001en_US
dc.identifier.scopus2-s2.0-82955189282en_US
dc.institutionauthorAkar, Mehmet Nejat-
dc.identifier.pmid27264580en_US
dc.identifier.doi10.5152/tjh.2011.43-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.scopusqualityQ4-
dc.identifier.trdizinid153010en_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeReview-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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