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Title: Host variations in SARS-CoV-2 infection
Authors: Altıok, Doruk
Savcı, Elif Zeynep
Özkara, Busra
Alkan, Kamil
Namdar, Dilara Sultan
Tuncer, Gizem
Kılınç, Buğrahan Regaip
Keywords: Angiotensin-converting enzyme 2 (ACE2)
host genetics
toll-like receptors (TLR)
transmembrane serine protease 2 (TMPRSS2)
Acute Respiratory Syndrome
Sars-Coronavirus Pathogenesis
Dna Methylation
Promoter Polymorphism
Gene Polymorphisms
Issue Date: 2021
Publisher: Tubitak Scientific & Technical Research Council Turkey
Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the Coronavirus Disease of 2019 (COVID-19), and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.
ISSN: 1300-0152
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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