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Title: Effects of granisetron on spinal anesthesia-induced hypotension
Other Titles: Granisetronun spinal anestezi kaynaklı hipotansiyona etkisi
Authors: Çataroğlu, C.K.
Alptekin, A.
Gezer, A.
Sayın, M.
Dönmez, A.
Keywords: Arterial pressure
Heart rate
Spinal anaesthesia
sodium chloride
blood pressure measurement
controlled study
drug effect
elective surgery
fifth lumbar vertebra
fourth lumbar vertebra
heart rate
induced hypotension
major clinical study
nausea and vomiting
randomized controlled trial
spinal anesthesia
Issue Date: 2021
Publisher: Anestezi Dergisi
Abstract: Objective: It was aimed to evaluate the effect of intravenous (IV) granisetron used for nausea and vomiting prophylaxis on hypotension and bradycardia caused by spinal anesthesia. Methods: 120 ASA 1-2 patients undergoing elective surgery under spinal anesthesia were randomly divided into Group G (Ganisetron; n=60) and Group P (Placebo; n=60) groups. Five minutes before spinal anesthesia, Group G received 1 mg intravenous granisetron diluted in 10 mL of isotonic sodium chloride solution and Group P received 10 mL of isotonic sodium chloride solution. Spinal anesthesia with hyperbaric bupivacaine 0.5%, 15 mg at the level of L4-5 was applied for both groups. Hemodynamic data, sensory and motor block parameters were recorded before and after spinal anaesthesia every 5 minutes during 20 minutes of surgery. Results: There was no difference in the demographic data of both groups. Although hemodynamic data showed a decrease in both groups according to initial values, blood pressure measurements in group G were significantly higher than the first measure values. There was no significant difference in heart rate values between the groups. Conclusion: Intravenous granisetron reduces hypotension after spinal anesthesia, but it has no significant effect on heart rate. © Copyright Anesthesiology and Reanimation Specialists’ Society. This journal published by Logos Medical Publishing. Licenced by Creative Commons Attribution 4.0 International (CC)
ISSN: 1300-0578
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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