Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8549
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dc.contributor.authorCelik, Humeyra-
dc.contributor.authorDursun, Ali Dogan-
dc.contributor.authorTatar, Yakup-
dc.contributor.authorOmercioglu, Goktug-
dc.contributor.authorBastug, Metin-
dc.date.accessioned2022-07-30T16:39:30Z-
dc.date.available2022-07-30T16:39:30Z-
dc.date.issued2022-
dc.identifier.citationCelik, H., Dursun, A. D., Tatar, Y., Omercioglu, G., & Bastug, M. (2022). Irisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmill. Sport Sciences for Health, 1-9.en_US
dc.identifier.issn1824-7490-
dc.identifier.issn1825-1234-
dc.identifier.urihttps://doi.org/10.1007/s11332-022-00924-1-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8549-
dc.description.abstractPurpose Exercise-mediated protection from cardiomyopathy in diabetes through myokines raises the question of what volume of exercise should be performed. Irisin pathway molecules (consisting of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), irisin, peroxisome proliferator-activated receptors-alpha (PPAR-alpha) and uncoupling protein 1 (UCP1)), which have been shown to be mostly expressed in the heart, are thought to have beneficial effects on diabetic heart. The aim of the study is to evaluate the effects of different exercise protocols on irisin pathway in Type 1 diabetic heart. Methods Diabetic (60 mg/kg streptozotocin i.p.) and healthy Wistar Albino rats (n = 60) were trained under moderate and high-volume exercise protocols on rat treadmill for 6 weeks. After killing, mRNA transcript and protein abundance of PGC-1 alpha, irisin, PPAR-alpha, and UCP1 were determined in the left ventricles of healthy and diabetic rats. Results PPAR-alpha, FNDC5, and UCP1 mRNA levels increased significantly in healthy moderate-volume exercise group (HMVE) compared to healthy high-volume exercise (HHVE) and diabetic moderate-volume exercise groups (DMVE). Moreover, protein levels of irisin and UCP1 also elevated significantly in the diabetic high-volume exercise group (DHVE) compared to the healthy control group (HC), although there was no significant difference between the groups in PPAR-alpha. Conclusion Irisin and UCP1 protein values increased due to HHEV in the heart of Type 1 diabetic rats, but PPAR-alpha values did not change; it shows that HHEV is suitable for the heart of Type 1 diabetic rats in terms of the benefits of the pathway of irisin.en_US
dc.description.sponsorshipAnkara University Research Funds [17L0230010, 15A0230006]en_US
dc.description.sponsorshipThis study was funded by Ankara University Research Funds (17L0230010 and 15A0230006).en_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofSport Sciences for Healthen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 1 diabetes mellitusen_US
dc.subjectExercise intensityen_US
dc.subjectIrisinen_US
dc.subjectDiabetic cardiomyopathyen_US
dc.subjectFNDC5en_US
dc.subjectHearten_US
dc.subjectCardiac Dysfunctionen_US
dc.subjectPhysical-Activityen_US
dc.subjectCardiovascular Risken_US
dc.subjectOxidative Stressen_US
dc.subjectPlasma Irisinen_US
dc.subjectSerum Irisinen_US
dc.subjectFaten_US
dc.subjectMellitusen_US
dc.subjectMuscleen_US
dc.subjectYoungen_US
dc.titleIrisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmillen_US
dc.typeArticleen_US
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentFaculties, Faculty of Science and Literature, Department of Psychologyen_US
dc.authoridDursun, Ali Dogan/0000-0001-9056-0025-
dc.identifier.wosWOS:000773183700001en_US
dc.identifier.scopus2-s2.0-85127303722en_US
dc.institutionauthorTatar, Yakup-
dc.identifier.doi10.1007/s11332-022-00924-1-
dc.authorwosidDursun, Ali Dogan/AAH-7617-2019-
dc.authorscopusid57555492800-
dc.authorscopusid57196954194-
dc.authorscopusid57210943925-
dc.authorscopusid57219303127-
dc.authorscopusid6506192760-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeArticle-
Appears in Collections:Psikoloji Bölümü / Department of Psychology
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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