Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8858
Title: Comparison of two sedation protocols on intraocular pressure and hemodynamic responses during colonoscopy
Authors: Bayraktaroglu M.
Kurtay A.
Horasanli E.
Keywords: Colonoscopy
Intraocular pressure
Ketamine
Sedation
ketamine
midazolam
propofol
hypnotic sedative agent
ketamine
midazolam
propofol
abdominal pain
adult
anesthesia level
Article
blood pressure
body mass
bradycardia
cancer screening
clinical protocol
colon
colonoscopy
constipation
controlled study
diarrhea
double blind procedure
drug safety
elective surgery
female
hemodynamics
hepatic flexure
human
hypertension
hypotension
hypoxia
ileocecal valve
intraocular pressure
iron deficiency anemia
major clinical study
male
nausea
occult blood
patient positioning
patient satisfaction
preoperative period
randomized controlled trial
tachycardia
vomiting
aged
colonoscopy
eye disease
hemodynamics
intraocular pressure
procedures
randomized controlled trial (topic)
Adult
Aged
Colonoscopy
Eye Diseases
Hemodynamics
Humans
Hypnotics and Sedatives
Intraocular Pressure
Ketamine
Midazolam
Propofol
Randomized Controlled Trials as Topic
Issue Date: 2022
Publisher: Verduci Editore s.r.l
Abstract: OBJECTIVE: Colonoscopy is one of the most frequently performed interventional endoscopic procedures for diagnosis and treatment. During the procedure, the increase in intraabdominal pressure can cause undesirable spikes in intraocular pressure. In the literature, there are no studies on agent combinations that cause the least effect on intraocular pressure and hemodynamic response in colonoscopic procedures, which are performed more frequently in the elderly, the patient group at the greatest risk for glaucoma. This study aimed to compare ketamine-propofol and ketamine-midazolam protocols in terms of their effects on hemodynamic parameters and intraocular pressure. MATERIALS AND METHODS: The research was a randomized clinical controlled double-blind study. The study was conducted on 60 healthy adults who underwent elective colonoscopy. Ketamin-midazolam and ketamine-propofol combinations were used. Hemodynamic parameters, intraocular pressures at five different times, and the satisfaction levels of the endoscopist and the patient were recorded. RESULTS: In both groups, there was a statistically significant difference between the pre-procedure intraocular pressure values and the values at the 1st minute of the procedure and at recovery (p<0.05). No statistically significant difference was found between the intraocular pressure values of the study groups at any time point (p>0.05). CONCLUSIONS: Both combinations can be used safely. The combination of ketamine and propofol in subanesthetic doses provides better sedation without disturbing the hemodynamics and is preferable. © 2022 Verduci Editore s.r.l. All rights reserved.
URI: https://doi.org/10.26355/eurrev_202206_29068
https://hdl.handle.net/20.500.11851/8858
ISSN: 1128-3602
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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